Prof C O'Brien all Glaucoma Research Publications
Showing 1 - 177 out of 177
177

Murtagh P, O’Brien C.

  • 2022
  • Corneal Hysteresis, Intraocular Pressure and Progression of Glaucoma: Time for a “Hyst-Oric” Change in Clinical Practice?
  • J Clin Med. 2022 May 20;11(10):2895. doi: 10.3390/jcm11102895
Reference Link
176

Hurley DJ, Normile C, Irnaten M, O’Brien C.

  • 2022
  • The Intertwined Roles of Oxidative Stress and Endoplasmic Reticulum Stress in Glaucoma.
  • Antioxidants (Basel). 2022 Apr 29;11(5):886. doi: 10.3390/antiox11050886
reference Link
175

Powell S, Irnaten M, O’Brien C.

  • 2022
  • Glaucoma – A Stiff Eye in a Stiff Body
  • Curr Eye Res. 2022 Mar 7:1-9. doi: 10.1080/02713683.2022.2039204.
reference Link
174

Powell S, Doolan E, Curtin K, Doyle A, O’Brien C.

  • 2022
  • Audit of outcomes following attendance at the City West drive-through IOP glaucoma clinic during COVID-19 pandemic.
  • Ir J Med Sci. 2022 Jan 16:1-10. doi: 10.1007/s11845-021-02893-9.
Reference Link
173

Murphy R, Irnaten M, Hopkins A, O Callaghan J, Stamer WD, Clark AF, Wallace D, O’Brien CJ.

  • 2022
  • Matrix Mechanotransduction via Yes-Associated Protein in Human Lamina Cribosa Cells in Glaucoma.
  • Invest Ophthalmol Vis Sci. 2022 Jan 3;63(1):16 doi: 10.1167/iovs.63.1.16.
Reference Link
172

Kelly RA, Perkumas KM, Campbell M, Farrar GJ, Stamer WD, Humphries P, O’Callaghan J, O’Brien CJ.

  • 2021
  • Fibrotic Changes to Schlemm’s Canal Endothelial Cells in Glaucoma.
  • Int J Mol Sci. 2021 Aug 31;22(17):9446. Doi 10.3390/ijms22179446.
Reference Link
171

Hurley DJ, Iranaten, O’Brien C.

  • 2021
  • Metformin and Glaucoma-Review of Anti-Fibrotic Processes and Bioenergetics.
  • Cells 2021 Aug 19;10(8):2131. Doi: 10.3390/cells10082131.
Reference Link
170

O’Regan A, O’Brien CJ, Eivers SB.

  • 2021
  • The lysophosphatidic acid axis in fibrosis: Implications for glaucoma.
  • Wound Repair Regen. 2021 Jul;29(4):613-626. doi: 10.1111/wrr.12929. Epub 2021 May 19.
Reference Link
169

Doolan E, O’Brien C.

  • 2021
  • Abnormal corneal properties in osteogenesis imperfect and glaucoma: a case series.
  • BMJ Open Ophthalmic. 2021 Apr15;6(1):e000684 doi: 10.1136/bmjophth-2020-000684. eCollection 2021.
Reference Link
168

Kamel K, Dervan E, Falzon K, O’Brien C.

  • 2020
  • Difference in intraocular pressure measurements between non-contact tonometry and Goldmann applanation tonometry and the role of central corneal thickness in affecting glaucoma referrals.
  • Ir J Med Sci. 2019 Feb;188(1):321-325. doi: 10.1007/s11845-018-1795-0. Epub 2018 Apr 4.
Reference Link
167

Cassidy PS, Kelly RA, Reina-Torres E, Sherwood JM, Humphries MM, Kiang AS, Farrar GJ, O’Brien C, Campbell M, Stamer WD, Overby DR, Humphries P, O’Callaghan J.

  • 2020
  • siRNA targeting Schlemm's canal endothelial tight junctions enhances outflow facility and reduces IOP in a steroid-induced OHT rodent model.
  • Mol Ther Methods Clin Dev. 2020 Oct 31;20:86-94. doi: 10.1016/j.omtm.2020.10.022. eCollection 2021 Mar 12.
Reference Link
166

Greene AG, Eivers SB, McDonnell F, Dervan EWJ, O’Brien CJ, Wallace DM.

  • 2020
  • Differential Lysyl oxidase like 1 expression in pseudoexfoliation glaucoma is orchestrated via DNA methylation.
  • Exp Eye Res. 2020 Dec;201:108349. doi: 10.1016/j.exer.2020.108349. Epub 2020
Reference Link
165

Irnaten M, Duff A, Clark A, O’Brien C.

  • 2020
  • Intra-Cellular Calcium Signaling Pathways (PKC, RAS/RAF/MAPK, PI3K) in Lamina Cribrosa Cells in Glaucoma.
  • J Clin Med. 2020 Dec 26;10(1):62. doi: 10.3390/jcm10010062.
Reference Link
164

Kamel K, O’Brien CJ, Zhdanov AV, Papkovsky DB, Clark AF, Stamer WD, Irnaten M.

  • 2020
  • Reduced Oxidative Phosphorylation and Increased Glycolysis in Human Glaucoma Lamina Cribrosa Cells.
  • Invest Ophthalmol Vis Sci. 2020 Nov 2;61(13):4. doi: 10.1167/iovs.61.13.4.
Reference Link
163

Hopkins AA, Murphy R, Irnaten M, Wallace DM, Quill B, O’Brien C.

  • 2020
  • The Role of Lamina Cribrosa Tissue Stiffness and Fibrosis as Fundamental Biomechanical Drivers of Pathological Glaucomatous Cupping.
  • Am J Physiol Cell Physiol. 2020 Jul 15. doi: 10.1152/ajpcell.00054.2020.
Reference Link
162

Rahman N, O’Neill E, Irnaten M, Wallace D, O’Brien C.

  • 2020
  • Corneal Stiffness and Collagen Cross-Linking Proteins in Glaucoma: Potential for Novel Therapeutic Strategy.
  • J Ocul Pharmacol Ther. 2020 Jul 13. doi: 10.1089/jop.2019.0118.
Reference Link
161

Eivers SB, Greene AG, Dervan E, O’Brien C, Wallace D

  • 2020
  • Prevalence of Pseudoexfoliation Glaucoma Risk-associated Variants Within Lysyl Oxidase-like 1 in an Irish Population.
  • J Glaucoma. 2020 Jun;29(6):417-422. doi:10.1097/IJG.0000000000001475.
Reference Link
160

Iraten M, O’Malley G, Clark AF, O’Brien CJ.

  • 2020
  • Transient receptor potential channels TRPC1/TRPC6 regulate lamina cribrosa cell extracellular matrix gene transcription and proliferation.
  • Exp Eye Res. 2020 Apr;193:107980. doi: 10.1016/j.exer.2020.107980. Epub 2020 Feb 20.
Reference Link
159

Greene AG, Eivers SB, Dervan EWJ,O’Brien CJ, Wallace DM.

  • 2020
  • Lysyl Oxidase Like 1: Biological roles and regulation.
  • Exp Eye Res. 2020 Apr;193107975. doi:10.1016/j.exer.2020.107975. Epub 2020 Feb15.
Reference Link
158

Murtagh P, Greene G, O’Brien C.

  • 2020
  • Current application of machine learning in the screening and diagnosis of glaucoma: a systematic review and Meta-analysis.
  • Int J Ophthalmic. 2020 Jan18;13(1):149-162
Reference Link
157

Bourke CM, Loughman J, Fltcroft DI, Loskutova E, O’Brien C.

  • 2019
  • We can't afford to turn a blind eye to myopia.
  • QJM. 2019 Mar 26. pii: hcz076. doi: 10.1093/qjmed/hcz076.
Reference Link
156

Andrews D, Oliviero G, De Chiara L, Watson A, Rochford E, Wynne K, Kennedy C, Clerkin S, Doyle B, Godson C, Connell P, O’Brien C, Cagney G, Crean J.

  • 2019
  • Unravelling the transcriptional responses of TGF-β: Smad3 and EZH2 constitute a regulatory switch that controls neuroretinal epithelial cell fate specification.
  • FASEB J. 2019 May;33(5):6667-6681. doi: 10.1096/fj.201800566RR
Reference Link
155

Loskutova E, O’Brien C, Loskutov I, Loughman J.

  • 2018
  • Nutritional supplementation in the treatment of glaucoma: A systematic review.
  • Surv Ophthalmol. 2018 Oct 6. pii: S0039-6257(18)30100-0.
Reference Link
154

Kamel K, Bourke L, O’Brien C.

  • 2018
  • Clinical and Laboratory Biomarkers for Pseudoexfoliation Syndrome.
  • J Glaucoma. 2018 Jul;27 Suppl 1:S111-S113.
Reference Link
153

Kamel K, Falzan K, Dervan E, O’Brien C.

  • 2018
  • Difference in intraocular pressure measurements between non-contact tonometry and Goldman applanation tonometry
  • Ir J Med Sci. 2018
Reference Link
152

Barrett C, O’Brien C, Loughman J.

  • 2018
  • Glaucoma referral refinement in Ireland: managing the sensitivity-specificity paradox in optometric practice.
  • Ophthalmic Physiol Opt. 2018 Feb 28. doi: 10.1111/opo.12446
Reference Link
151

Irnaten M, Zhdanov A, Brennan D, Crotty T, Clark A, Papkovsky D, O’Brien C.

  • 2018
  • Activation of the NFAT-Calcium Signaling Pathway in Human Lamina Cribrosa Cells in Glaucoma.
  • Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):831-842. doi: 10.1167/iovs.17-22531.
Reference Link
150

Liu B, Kilpatrick JI, Lukasz B, Jarvis SP, McDonnell F, Wallace DM, Clark AF, O’Brien CJ.

  • 2018
  • Increased Substrate Stiffness Elicits a Myofibroblastic Phenotype in Human Lamina Cribrosa Cells.
  • Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):803-814. doi: 1
Reference Link
149

Siah WF, O’Brien C, Loughman JJ.

  • 2017
  • Macular pigment is associated with glare-affected visual function and central visual field loss in glaucoma.
  • Br J Ophthalmol. 2017 Oct 5. pii: bjophthalmol-2017-310215. doi: 10.1136/bjophthalmol-2017-310215. [Epub ahead of print]
Reference Link
148

Kamel K, Farrell M, O’Brien C.

  • 2017
  • Mitochondrial dysfunction in ocular disease: Focus on glaucoma.
  • Mitochondrion. 2017 Jul;35:44-53. doi: 10.1016/j.mito.2017.05.004. Epub 2017 May 9.
Reference Link
147

Liu B, McNally S, Kilpatrick JI, Jarvis SP, O’Brien CJ.

  • 2017
  • Aging and ocular tissue stiffness in glaucoma.
  • Surv Ophthalmol. 2017 Jun 27. pii: S0039-6257(15)30018-7. doi: 10.1016/j.survophthal.2017.06.007
Reference Link
146

Barrett C, O’Brien C, Butler JS, Loughman J.

  • 2017
  • Barriers to glaucoma case finding as perceived by optometrists in Ireland.
  • Clin Exp Optom. 2017 Jul 17. doi: 10.1111/cxo.12573.
Reference Link
145

Wallace DM, Pokrovskaya O, O’Brien CJ.

  • 2015
  • The Function of Matricellular Proteins in the Lamina Cribrosa and Trabecular Meshwork in Glaucoma.
  • J Ocul Pharmacol Ther. 2015 Sep;31(7):386-95. doi: 10.1089/jop.2014.0163. Epub 2015 Apr 7. Review.
Reference Link
144

O’Callaghan J, Crosbie DE, Cassidy PS, Sherwood JM, Flügel-Koch C, Lütjen-Drecoll E, Humphries MM, Reina-Torres E, Wallace D, Kiang AS, Campbell M, Daniel SW, Overby DR, O’Brien C, Tam LC, Humphries P.

  • 2017
  • Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma.
  • Hum Mol Genet. 2017 Feb 1. doi: 10.1093/hmg/ddx028.
Reference Link
143

Murphy ML, Pokrovskaya O, Galligan M, O’Brien C.

  • 2017
  • Corneal hysteresis in patients with glaucoma-like optic discs, ocular hypertension and glaucoma.
  • BMC Ophthalmol. 2017 Jan 10;17(1):1. doi: 10.1186/s12886-016-0396-9.
Reference Link
142

McDonnell FS, McNally SA, Clark AF, O’Brien CJ, Wallace DM.

  • 2016
  • Increased Global DNA Methylation and Decreased TGFβ1 Promoter Methylation in Glaucomatous Lamina Cribrosa Cells.
  • J Glaucoma. 2016 Oct;25(10):e834-e842.
Reference Link
141

Paula JS, O’Brien C, Stamer WD.

  • 2016
  • Life under pressure: The role of ocular cribriform cells in preventing glaucoma.
  • Exp Eye Res. 2016 Oct;151:150-9. doi: 10.1016/j.exer.2016.08.014. Epub 2016 Aug 25. Review.
Reference Link
140

Treacy MP, O’Neill EC, Murphy M, O’Toole L, Delaney Y, O’Brien C, Connell PP.

  • 2016
  • Opportunistic detection of glaucomatous optic discs within a diabetic retinopathy screening service.
  • Eur J Ophthalmol. 2016 Jun 10;26(4):315-20. doi: 10.5301/ejo.5000722. Epub 2015 Dec 17.
Reference Link
139

McDonnell F, Irnaten M, Clark AF, O’Brien CJ, Wallace DM.

  • 2016
  • Hypoxia-Induced Changes in DNA Methylation Alter RASAL1 and TGFβ1 Expression in Human Trabecular Meshwork Cells.
  • PLoS One. 2016 Apr 28;11(4):e0153354. doi: 10.1371/journal.pone.0153354. eCollection 2016 Apr 28.
Reference Link
138

Pokrovskaya O, O’Brien C.

  • 2016
  • What's in a Gene? Pseudoexfoliation Syndrome and Pigment Dispersion Syndrome in the Same Patient.
  • Case Rep Ophthalmol. 2016 Jan 21;7(1):54-60. doi: 10.1159/000443697. eCollection 2016 Jan 21.
Reference Link
137

Murphy RM, Bakir B, O’Brien C, Wiggs JL, Pasquale LR.

  • 2016
  • Drug-induced Bilateral Secondary Angle-Closure Glaucoma: A Literature Synthesis.
  • J Glaucoma. 2016 Feb;25(2):e99-e105.
Reference Link
136

O’Brien C, Clark AF.

  • 2016
  • Introduction to EER Special Issue on ocular fibrosis.
  • Exp Eye Res. 2016 Jan;142:1.
Reference Link
135

Wallace DM, O’Brien CJ. The role of lamina cribrosa cells in optic nerve head fibrosis in glaucoma.

  • 2016
  • The role of lamina cribrosa cells in optic nerve head fibrosis in glaucoma.
  • Exp Eye Res. 2016 Jan;142:102-9.
Reference Link
134

Quill B, Henry E, Simon E, O’Brien CJ.

  • 2015
  • Evaluation of the Effect of Hypercapnia on Vascular Function in Normal Tension Glaucoma.
  • Biomed Res Int. 2015;2015:418159.
Reference Link
133

Siah WF, Loughman J, O’Brien C.

  • 2015
  • Lower Macular Pigment Optical Density in Foveal-Involved Glaucoma.
  • Ophthalmology. 2015 Oct;122(10):2029-37.
Reference Link
132

Wallace DM, Pokrovskaya O, O’Brien CJ.

  • 2015
  • The Function of Matricellular Proteins in the Lamina Cribrosa and Trabecular Meshwork in Glaucoma.
  • J Ocul Pharmacol Ther. 2015 Sep;31(7):386-95.
Reference Link
131

Murphy RM, Bakir B, O’Brien C, Wiggs JL, Pasquale LR

  • 2015
  • Drug-induced Bilateral Secondary Angle-Closure Glaucoma: A Literature Synthesis.
  • J Glaucoma. 2015 Apr 21. [Epub ahead of print]
Reference Link
130

Wallace DM, Pokrovskaya O, O’Brien CJ.

  • 2015
  • The function of matricellular proteins in the lamina cribrosa and trabecular meshwork in glaucoma.
  • J Ocul Pharmacol Ther. 2015 Apr 7. [Epub ahead of print]
Reference Link
129

Quill B, Irnaten M, Docherty NG, McElnea EM, Wallace DM, Clark AF, O’Brien CJ

  • 2015
  • ‘Calcium channel blockade reduces mechanical strain induced extracellular matrix gene response in lamina cribrosa cells’.
  • Br J Ophthalmol. 2015 Mar 20. pii: bjophthalmol-2014-306093. doi: 10.1136/bjophthalmol-2014-306093. [Epub ahead of print]
Reference Link
128

McElnea EM, Hughes E, McGoldrick A, McCann A, Quill B, Docherty N, Irnaten M, Farrell M, Clark AF, O’Brien CJ, Wallace DM.

  • 2014
  • Lipofuscin accumulation and autophagy in glaucomatous human lamina cribrosa cells.
  • BMC Ophthalmol. 2014 Dec 2;14:153.
Reference Link
127

McNally S,  O’Brien CJ. Metabolomics/Proteomics strategies used to identify biomarkers for exfoliation glaucoma. J Glaucoma. 2014 Oct-Nov;23(8 Suppl 1):S51-4.

  • 2014
  • Metabolomics/Proteomics strategies used to identify biomarkers for exfoliation glaucoma.
  • J Glaucoma. 2014 Oct-Nov;23(8 Suppl 1):S51-4.
Reference Link
126

Sundaresan P, Simpson DA, Sambare C, Duffy S, Lechner J, Dastane A, Dervan EW, Vallabh N, Chelerkar V, Deshpande M, O’Brien C, McKnight AJ, Willoughby CE

  • 2014
  • Whole-mitochondrial genome sequencing in primary open-angle glaucoma using massively parallel sequencing identifies novel and known pathogenic variants.
  • Genet Med. 2014 Sep 18.
Reference Link
125

Gao W, Ferguson G, Connell P, Walshe T, O’Brien C, Redmond EM, Cahill PA.

  • 2014
  • Glucose attenuates hypoxia-induced changes in endothelial cell growth by inhibiting HIF-1α expression.
  • Diab Vasc Dis Res. 2014 May 22;11(4):270-280.
Reference Link
124

McDonnell F, O’Brien C, Wallace D.

  • 2014
  • The role of epigenetics in the fibrotic processes associated with glaucoma.
  • J Ophthalmol. 2014~:750459.
Reference Link
123

Wallace DM, Murphy-Ullrich JE, Downs JC, O’Brien CJ

  • 2014
  • The role of matricellular proteins in glaucoma.
  • Matrix Biol 2014 Apr 12 pii S0945-053X(14)00058-4
Reference Link
122

Wallace DM, Clarke AF, Lipson KE, Andrews D, Crean JK, O’Brien CJ .

  • 2013
  • Anti-connective tissue growth factor antibody treatment reduces extracellular matrix production in trabecular meshwork and lamina cribrosa cells.
  • Invest Ophthalmol Vis Sci 2013 Dec 2;54(13)7836-48
Reference Link
121

Irnaten M, Barry RC, Wallace DM, Docherty NG, Quill B, Clark AF, O’Brien CJ.

  • 2013
  • Elevated maxi-K(+) ion channel current in glaucomatous lamina cribrosa cells
  • Exp Eye Res 2013 Oct; 115:224-9
Reference Link
120

Igras E, Loughman J, Ratzlaff M, O’Caoimh R, O’Brien C.

  • 2013
  • Evidence of lower macular pigment optical density in chronic open angle glaucoma. Br J Ophthalmol. 2013 Aug;97(8):994-998
  • Br J Ophthalmol. 2013 Aug;97(8):994-998
Reference Link
119

Bhattacharya SK, Lee RK, Grus FH; 

  • 2013
  • Seventh ARVO/Pfizer Ophthalmics Research Institute Conference Working Group. Molecular biomarkers in glaucoma.
  • 2013 Jan 7;54(1):121-31
118

Kirwan RP, Felice L, Clark AF, O’Brien CJ, Leonard MO.

  • 2012
  • Hypoxia regulated gene transcription in human optic nerve lamina cribrosa cells in culture.
  • Invest Ophthalmol Vis Sci. 2012 53:2243-2255
Reference Link
117

Wiggs JL, Hewitt AW, Fan BJ, Wang DY, Figueiredo Sena DR, O’Brien C, Realini A, Craig JE, Dimasi DP, Mackey DA, Haines JL, Pasquale LR.

  • 2012
  • The p53 codon 72 PRO/PRO genotype may be associated with initial central visual field defects in caucasians with primary open angle glaucoma.
  • PLoS One. 2012;7(9):e45613. doi: 10.1371/journal.pone.0045613. Epub 2012 Sep 26
Reference Link
116

Walshe TE, Connell P, Cryan L, Ferguson G, Gardiner T, Morrow D, Redmond EM, O’Brien C, Cahill PA

  • 2011
  • Microvascular retinal endothelial and pericyte cell apoptosis in vitro: role of Hedgehog and Notch signaling.
  • Invest Ophthalmol Vis Sci. 2011 . Jun 23;52(7):4472-83.
Reference Link
115

Browne JG, Ho SL, Kane R, Oliver N, Clark AF, O’Brien CJ, Crean JK.

  • 2011
  • Connective Tissue Growth Factor is increased in Pseudoexfoliation Glaucoma.
  • Invest Ophthalmol Vis Sci. 2011 Jun 1;52(6):3660-6
Reference Link
114

Gallagher BA, Hart PM, O’Brien C, Stevenson MR, Jackson AJ.

  • 2011
  • Mobility and access to transport issues as experienced by people with vision impairment living in urban and rural Ireland.
  • Disabil Rehabil. 2011;33(12):979-88.
Reference Link
113

McElnea EM, Quill B, Docherty NG, Irnaten M, Siah WF, Clark AF, O’Brien CJ, Wallace DM

  • 2011
  • Oxidative stress, mitochondrial dysfunction and calcium overload in human lamina cribrosa cells from glaucoma donors.
  • Mol Vis. 2011;17:1182-91.
Reference Link
112

Guerin M, Cotter T, McKernan D, O’Brien C.

  • 2011
  • Age Dependent Rat Retinal Ganglion Cell Susceptibility to Apoptotic Stimuli: Implications for Glaucoma.
  • Clin & Exper Ophthalmol Apr;39(3):243-51. 2011
Reference Link
111

Quill B, Docherty N, Clark AF, O’Brien CJ.

  • 2011
  • The Effect of Graded Cyclic Stretch on Extracellular Matrix Related Gene Expression Profiles in Cultured Primary Human Lamina Cribrosa Cells.
  • Invest Ophthalmol Vis Sci. 2011; Mar 30;52(3):1908-15.
Reference Link
110

Farrell SM, Groeger G, Bhatt L, Finnegan S, O’Brien CJ, Cotter TG.

  • 2011
  • bFGF-mediated redox activation of the PI3K/Akt pathway in retinal photoreceptor cells.
  • Eur J Neurosci. 2011 Feb;33(4):632-41.
Reference Link
109

Walshe TE, Connell P, Cryan L, Ferguson G, O’Brien C, Cahill PA.

  • 2011
  • The role of pulsatile flow in controlling microvascular retinal endothelial and pericyte cell apoptosis and proliferation.
  • Cardiovasc Res. 2011 Feb 15;89(3):661-70.
Reference Link
108

P O’Connor R, Cryan LM, Wynne K, de Stefani A, Fitzgerald D, O’Brien C, Cagney G.

  • 2010
  • Proteomics strategy for identifying candidate bioactive proteins in complex mixtures: application to the platelet releasate.
  • J Biomed Biotechnol. 2010; 2010:107859.
Reference Link
107

Dervan EW, Chen H, Ho SL, Brummel N, Schmid J, Toomey D, Haralambova M, Gould E, Wallace DM, Prehn JH, O’Brien C, Murphy D.

  • 2010
  • Protein Macroarray Profiling of Serum Autoantibodies in Pseudoexfoliation Glaucoma.
  • Invest Ophthalmol Vis Sci. 2010 Jun;51(6):2968-75.
Reference Link
106

Quaranta L, Konstas AG, Rossetti L, Garcia-Feijoo J, O’Brien C, Nasr MB, Fogagnolo P, Demos CM, Stewart JA, Stewart WC.

  • 2010
  • Untreated 24-h intraocular pressures measured with Goldmann applanation tonometry vs nighttime supine pressures with Perkins applanation tonometry.
  • Eye (Lond). 2010 Jul;24(7):1252-8. Epub 2009 Dec 4.
Reference Link
105

Kirwan RP, Wordinger RJ, Clark AF, O’Brien CJ.

  • 2009
  • Differential global and extra-cellular matrix focused gene expression patterns between normal and glaucomatous human lamina cribrosa cells.
  • Mol Vis. 2009;15:76-88. Epub 2009 Jan 15.
Reference Link
104

Irnaten M, Barry RC, Quill B, Clark AF, Harvey BJ, O’Brien CJ.

  • 2009
  • Activation of stretch-activated channels and maxi-K+ channels by membrane stress of human lamina cribrosa cells.
  • Invest Ophthalmol Vis Sci. 2009 Jan;50(1):194-202. Epub 2008 Sep 4.
Reference Link
103

Cryan L, Fitzgerald D, O’Brien C.

  • 2009
  • Ocular prostaglandin production and morphology in mice lacking a single isoform of cyclogenase.
  • Prostaglandins, Leuko & Essent Fatty Acids 2009 81:401-9.
Reference Link
102

Guerin M, Flynn T, Brady J, O’Brien C.

  • 2008
  • Worldwide geographical distribution of ophthalmic publications.
  • Int Ophthalmol; 2008; 29: 511-6.
Reference Link
101

Cryan L, O’Brien C.

  • 2008
  • Proteomics as a research tool in clinical and experimental ophthalmology.
  • Proteomics Clin. App. 2008; 2(5); 762-75
Reference Link
100

Morrow D, Guha S, Sweeney C, Birney Y, Walshe T, O’Brien C, Walls D, Redmond EM, Cahill PA.

  • 2008
  • Notch and vascular smooth muscle cell phenotype.
  • Circ Res. 2008 Dec 5;103(12):1370-82.
Reference Link
099

O’Connor JC, Wallace DM, O’Brien C, Cotter TG. A novel antioxidant function for the tumour suppressor gene p53 in the retinal ganglion cell.

  • 2008
  • A novel antioxidant function for the tumour suppressor gene p53 in the retinal ganglion cell.
  • Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4237-44
Reference Link
098

Kane R, Godson C, O’Brien C.

  • 2008
  • Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis.
  • Mol Vis. 2008 Jun 20;14:1138-48.
Reference Link
097

O’Driscoll C, O’Connor J, O’Brien CJ, Cotter TG.

  • 2008
  • Basic fibroblast growth factor-induced protection from light damage in the mouse retina in vivo.
  • J Neurochem. 2008 Apr;105(2):524-36. Epub 2007 Dec 13.
Reference Link
096

Aragon-Martin JA, Ritch R, Liebmann J, O’Brien C, Blaaow K, Mercieca F, Spiteri A, Cobb CJ, Damji KF, Tarkkanen A, Rezaie T, Child AH, Sarfarazi M.

  • 2008
  • Evaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma.
  • Mol Vis. 2008 Mar 17;14:533-41.
Reference Link
095

Cryan LM, Paraoan L, Hiscott P, Damato BE, Grierson I, Gray D, Farrell M, Doherty GA, Fitzgerald DJ, O’Brien C.

  • 2008
  • Expression of COX-2 and prognostic outcome in uveal melanoma.
  • Curr Eye Res. 2008 Feb;33(2):177-84.
Reference Link
094

Horgan N, Kirwan RP, O’Brien CJ.

  • 2007
  • Choroidal detachment associated with latanoprost use in the fellow eye.
  • Ann Pharmacother. 2007 Jan;41(1):161-2.
Reference Link
093

Gao W, Ferguson G, Connell P, Walshe T, Murphy R, Birney YA, O’Brien C, Cahill PA.

  • 2007
  • High glucose concentrations alter hypoxia-induced control of vascular smooth muscle cell growth via a HIF-1alpha-dependent pathway.
  • J Mol Cell Cardiol. 2007 Mar;42(3):609-19. Epub 2006 Dec 21.
Reference Link
092

Connell P, Walshe T, Ferguson G, Gao W, O’Brien C, Cahill PA.

  • 2007
  • Elevated glucose attenuates agonist- and flow-stimulated endothelial nitric oxide synthase activity in microvascular retinal endothelial cells.
  • Endothelium. 2007 Jan-Feb;14(1):17-24.
Reference Link
091

Lee H, O’Meara SJ, O’Brien C, Kane R.

  • 2007
  • The role of gremlin, a BMP antagonist, and epithelial-to-mesenchymal transition in proliferative vitreoretinopathy.
  • Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4291-9.
Reference Link
090

McKernan DP, Guerin MB, O’Brien CJ, Cotter TG. A key role for calpains in retinal ganglion cell death.

  • 2007
  • Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5420-30.
Reference Link
089

Guerin MB, McKernan DP, O’Brien CJ, Cotter TG.

  • 2006
  • Retinal ganglion cells: dying to survive.
  • Int J Dev Biol. 2006;50(8):665-74..
Reference Link
088

Y Delaney, T Walshe, C O’Brien.

  • 2006
  • Vasospasm in glaucoma: clinical and laboratory aspects.
  • Optom Vis Sci. 2006 Jul;83(7):406-14.
Reference Link
087

E Henry, D Newby, DJ Webb, PW Hadoke, C O’Brien.

  • 2006
  • Altered endothelin-1 vasoreactivity in patients with untreated normal-pressure glaucoma.
  • Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2528-32.
Reference Link
086

L Cryan, G Pidgeon, D Fitzgerald, C O’Brien.

  • 2006
  • COX-2 protects against thrombosis of the retinal vasculature in a mouse model of proliferative retinopathy.
  • Mol Vis. 2006 Apr 20;12:405-14
Reference Link
085

C Kelliher, D Kenny, C O’Brien.

  • 2006
  • Trends in blind registration in the adult population of the Republic of Ireland. 1996-2003.
  • Br J Ophthalmol 2006 Mar;90(3)367-71.
Reference Link
084

McKernan DP, Caplis C, Donovan M, O’Brien C, Cotter T.

  • 2006
  • Age-dependent susceptibility of the retinal ganglion cell layer to cell death.
  • Invest Ophthalmol Vis Sci. 2006 Mar;47(3):807-14.
Reference Link
083

A Knox, M Barry, C O’Brien.

  • 2006
  • The rising cost of glaucoma drugs in Ireland. 1996-2003.
  • Br J Ophthalmol 2006 Feb;90(2):162-5
Reference Link
082

R Kane, L Stevenson, C Godson, A Stitt, C O’Brien.

  • 2005
  • Gremlin gene expression in bovine retinal pericytes exposed to elevated glucose.
  • Br J Ophthalmol 2005; Dec;89(12): 1638-42
Reference Link
081

R Kirwan, C Fenerty, J Crean, R Wordinger, A F Clark, C O’Brien

  • 2005
  • Influence of cyclical mechanical strain on extracellular matrix gene expression in human lamina cribrosa cells in vitro.
  • Mol Vis 2005 Sep 23;11:798-810
Reference Link
080

R Kirwan, M O’Leonard, M Murphy A F Clark, C O’Brien

  • 2005
  • Transforming growth factor-beta-regulated gene transcription and protein expression in human GFAP-negative lamina cribrosa cells.
  • Glia. 2005 Dec;52(4):309-24.
Reference Link
079

VW Long, C O’Brien.

  • 2005
  • Trends in ophthalmic surgery in Ireland.
  • Irish Journal Med. Sci 2005; 174 (2); 36-39
Reference Link
078

P Aspinall, A Hill, P Nelson, C O’Brien, E O’Connell, L McCloughan, A Azuara-Blanco, R Brice, S Green, C Steeds.

  • 2005
  • Quality of life in patients with glaucoma: a conjoint analysis approach.
  • Visual Impairment Research 2005; 7 (1): 13-26.
Reference Link
077

T E Walshe, G Ferguson, P Connell, C O’Brien, P A Cahill.

  • 2005
  • Pulsatile flow increases the expression of eNOS, ET-1, and Prostacyclin in a novel in vitro coculture model of the retinal vasculature.
  • Invest Ophthal Vis Sci 2005;Jan(46)1:375-382.
Reference Link
076

C Cleary, C H Buckley, E Henry, P McLoughlin, C O’Brien, P W Hadoke.

  • 2005
  • Enhanced endothelium derived hyperpolarized factor activity in resistance arteries from normal pressure glaucoma patients: implications for vascular function in the eye.
  • Br J Ophthalmol 2005;89:223-228
Reference Link
075

S L Ho, G F Dogar, J Wang, J Crean, Q D Wu, N Oliver, S Weitz, A Murray, P E Cleary, C O’Brien.

  • 2005
  • Elevated aqueous humour tissue inhibitor of matrix metalloproteinase-1 and connective tissue growth factor in pseudoexfoliation disease.
  • Br J Ophthalmol 2005;89:169-173.
Reference Link
074

Morgan-Davies J, Taylor N, Hill AR, Aspinall P, O’Brien CJ, Asuara-Blanco A.

  • 2004
  • Three dimensional analysis of the lamina cribrosa in glaucoma.
  • Br J Ophthalmol 2004 Oct;88(10): 1299-304.
Reference Link
073

R Kirwan, J Crean, C Fenerty, A Clark, C O’Brien.

  • 2004
  • Effect of cyclical mechanical stretch and exogenous transforming growth factor-B1 on matrix metalloproteinase-2 activity in lamina cribrosa cells from the human optic nerve head.
  • J Glaucoma 2004 Aug; 13(4): 327-34.
Reference Link
072

J Stokes, R Best, C O’Brien, J Seckl.

  • 2003
  • Altered glucocorticoid peripheral sensitivity in glaucoma.
  • Invest Ophthal Vis Sci 2003; Dec 44(12) 5163-7.
Reference Link
071

J Kerr, C O’Brien.

  • 2003
  • Ocular blood flow in untreated ocular hypertension.
  • Am J Ophthalmology 2003 Dec 136(6) 1106-13.
Reference Link
070

S Quinn, C O’Brien, P McLoughlin.

  • 2003
  • Nitric oxide independent vasorelaxation in the bovine long posterior ciliary artery.
  • Eye 2003 July 17(5) 628-36.
Reference Link
069

P Nelson, P Aspinall, C O’Brien.

  • 2003
  • The relationship between quality of life and visual function in glaucoma.
  • J Glaucoma 2003 Apr 12(2) 139-50.
Reference Link
068

Buckley C, Hadoke P, Henry E, O’Brien C.

  • 2002
  • Systemic vascular endothelial dysfunction in normal pressure glaucoma
  • Br J Ophthalmology 2002; 86; 227-32.
Reference Link
067

O’Toole L, Cahill M, O’Brien C.

  • 2001
  • Eyelid hypertrichosis associated with latanoprost is reversible.
  • Eur J Ophthalmol. 2001 Oct-Dec;11(4):377-9.
Reference Link
066

Devlin H, O’Brien C.

  • 2001
  • Normal tension glaucoma: Diagnosis and Management.
  • CME Journal Ophthalmol 2001; 5(1): 13-17.
065

Morgan-Davies J, King A, Aspinall P, O’Brien C.

  • 2000
  • Measurement of a novel optic disc topographic parameter ‘spikiness’ in glaucoma.
  • Graefe’s Arch Clin Exp Ophthalmol 2000, 238: 669- 76.
Reference Link
064

McKinnon J, McKillop G, Swa K, O’Brien C, Butt Z, Nelson P.

  • 2000
  • Colour Doppler imaging of the ocular circulation in diabetic retinopathy.
  • Acta Ophthalmol, 2000, 78: 386-9.
Reference Link
063

Stokes J, Andrew R, Seckyl J, O’Brien C.

  • 2000
  • Glucocorticoid and mineralocorticoid receptors and 11-beta-deyhydrogenase activity in rat and human ocular tissue.
  • Invest Ophthalmol Vis Sci 2000; 41: 1629-38.
Reference Link
062

King A, Bolton N, Aspinall P, O’Brien C.

  • 2000
  • Retinal nerve fibre layer volume in glaucoma.
  • Am J Ophthalmol 2000, 129: 599-607.
Reference Link
061

J Stokes, E Henry, C O’Brien.

  • 1998/1999
  • Differential Diagnosis of Normal Tension Glaucoma (1998)
  • In: Pillunat L, Harris A (eds) Fortbildurg Glaucoma. Enke Verlag, Stuggart, 1999.
060

O’Brien C, Butt Z.

  • 1999
  • Blood flow velocity in the peripheral circulation of glaucoma patients.
  • Ophthalmologica 1999; 213: 150-153.
Reference Link
059

Henry E, Newby DE, Webb DJ, O’Brien C.

  • 1999
  • Peripheral endothelial dysfunction in normal pressure glaucoma.
  • Invest Ophthalmol Vis Sci 1999; 40: 1710-1714.
Reference Link
058

Nelson P, Aspinall P, O’Brien C.

  • 1999
  • Patients’ perception of visual impairment in glaucoma. A pilot study.
  • Br J Ophthalmol 1999; 83: 546-552.
Reference Link
057

Edgar DF, Crabb DP, Rudnicka AR, Lawrensen JG, Gutteridge NM, O’Brien C.

  • 1999
  • Effects of dipivefrin and pilocarpine on pupil diameter, automated perimetry and Logmar acuity.
  • Graefe’s Arch Clin Exp Ophthalmol 1999; 237: 117-24.
Reference Link
056

Buckley C H, Hadoke P, O’Brien C.

  • 1998
  • Role of the endothelium in modulating functional responses of isolated bovine anterior ciliary arteries to vasoconstrictor agonists.
  • Br J Ophthalmol 1998; 82: 826-829.
Reference Link
055

Fontana L, Poinoosawmy D, Bunce CV, O’Brien C, Hitchings RA.

  • 1998
  • Pulsatile ocular blood flow investigation in asymmetric normal-tension glaucoma and normal subjects.
  • Br J Ophthalmol 1998; 82: 731-6.
Reference Link
054

Kelly PA, Buckley C, Ritchie IM, O’Brien C.

  • 1998
  • Possible role for nitric oxide releasing nerves in the regulation of ocular blood flow in the rat.
  • Br J Ophthalmol 1998; 82: 1199-202.
Reference Link
053

O’Brien C

  • 1998
  • Vasospasm and glaucoma (Editorial).
  • Br J Ophthalmol 1998; 82: 855-6.
Reference link
052

Kerr J, Nelson P, O’Brien C.

  • 1998
  • A comparison of ocular blood flow in untreated primary open-angle glaucoma and ocular hypertension.
  • Am J Ophthalmol 1998; 126: 42-51.
Reference link
051

C. O’Brien.

  • 1998
  • Is there a role for computerised image analysis in glaucoma management.
  • Br. J Ophthalmol 1998, 82: 2-3. (Editorial).
Reference link
050

C Buckley, P Hadoke, C O’Brien.

  • 1997
  • The use of isolated ocular arteries in-vitro to define the pathology of vascular changes in glaucoma.
  • Br J Ophthalmol 1997, 81:599 - 607
Reference Link
049

JR Mackinnon, Z Butt, K Swa, C O’Brien.

  • 1997
  • Pulsatile ocular blood flow in untreated diabetic retinopathy.
  • Acta Ophthalmol, 1997; 75:6, 661-4.
Reference Link
048

RWD Bell, NE Habib, C O’Brien.

  • 1997
  • Long-term outcome and complications of trabeculectomy with a single per-operative application of 5-fluorouracil.
  • Eye 1997;11: 663-71.
Reference Link
047

RS Anderson, C O’Brien.

  • 1997
  • Psychophysical evidence for selective loss of M ganglion cells in glaucoma
  • Vis Res 1997 , 37: 1079-1083.
Reference Link
046

RWD Bell, HK Yang, C O’Brien.

  • 1997
  • A case of bilateral cavernous hemangioma associated with intra-cerebral hemangioma.
  • Arch Ophthalmol 1997, 115:6, 818-9.
Reference Link
045

C O’Brien, Z Butt, C Ludlum.

  • 1997
  • Activation of the coagulation cascade in untreated primary open angle glaucoma.
  • Ophthalmol 1997; 104:725 - 730
Reference Link
044

Z Butt, C O’Brien, G McKillop, P Aspinall, P Allan.

  • 1997
  • Colour Doppler imaging in untreated high and normal pressure open angle glaucoma.
  • Invest Ophthalmol Vis Sci, 1997; 38: 690-6.
Reference Link
043

C O’Brien, P Kelly, I Ritchie.

  • 1997
  • The effect of chronic inhibition of nitric oxide synthase on ocular blood flow and glucose metabolism in rats.
  • Br J Ophthalmol 1997;81:68-71.
Reference Link
042

RWD Bell, C O’Brien.

  • 1997
  • Accuracy of referral to a glaucoma clinic.
  • Ophthal Physiol Opt 1997;17:7-11.
Reference Link
041

RWD Bell, C O’Brien.

  • 1997
  • Diagnostic outcome of hospital glaucoma referrals.
  • Ophthal Physiol Opt 1997;17:3-6.
Reference Link
040

A Kosmin, M Austin, C.O’Brien, N. Cotu, P. Wishart.

  • 1996/1997
  • Ageing changes in automated perimetry. A comparison of flicker and luminance sensitivity in normal subjects.
  • In: Wall M, Heijl A (eds). Perimetry update 1996/1997. Kugler: Amsterdam, New York 1997, pp 229 - 233.
039

FD Ghanchi, TH Williamson, CS Lim, Z Butt, GM Baxter, G McKillop, C O’Brien.

  • 1996
  • Colour Doppler imaging in giant cell (temporal) arteritis: serial examination and comparison with non-arteritic anterior ischaemic optic neuropathy.
  • Eye 1996;10:459-464.
Reference Link
038

C Lim, C O’Brien, N Bolton.

  • 1996
  • A simple clinical method to measure the optic disc size in glaucoma.
  • J Glaucoma 1996;5:241-245.
Reference Link
037

J Sing, R Bell, A Adams, C O’Brien,

  • 1996
  • Enhancement of post trabeculectomy bleb formation by laser suture lysis.
  • Br J Ophthalmol 1996;80:624-627.
Reference Link
036

RS Ayyala, C O’Brien, I Grierson, P Maltby.

  • 1996
  • Transcleral flow of aqueous humor: an in-vitro experiment.
  • Ophthalmol Surg 1996;27:66-69.
Reference Link
035

M Birch, S Barbosa, L Blumhardt, C O Brien, S Harding.

  • 1996
  • Retinal venous sheathing and the blood-retinal barrier in multiple sclerosis.
  • Arch Ophthalmol 1996;114-119.
Reference Link
034

RS Anderson, P Detkova, C O’Brien.

  • 1995
  • Effect of temporal frequency and contrast on peripheral grating resolution.
  • Curr Eye Res 1995;14:1031-1033.
Reference Link
033

GP Rao, C O’Brien, MH Dwyer, A Patterson.

  • 1995
  • Rapid onset bilateral calcific band keratopathy associated with phosphate containing steroid eye drops.
  • Eur J Implant Refr Surg 1995;7:251-252.
Reference Link
032

A King, D David, H Jones, C O’Brien.

  • 1995
  • Non-attendance at an ophthalmic out-patient department.
  • J Roy Soc Med 1995;88:88-90.
Reference Link
031

J Sing, H Chawla, C O’Brien.

  • 1995
  • Success rate and complications of intraoperative mitomycin-C in trabeculectomy surgery.
  • Eye 1995;9:460-466.
reference Link
030

Z Butt, C O’Brien.

  • 1995
  • Reproducibility of pulsatile ocular blood flow measurements.
  • J Glaucoma 1995;4:214-218.
Reference Link
029

C O’Brien, J Wild.

  • 1995
  • Automated perimetry in glaucoma - room for improvement?
  • Br J Ophthalmol 1995;79:200-201. (editorial)
Reference Link
028

Z Butt, G McKillop, C O’Brien, P Allan, P Aspinall.

  • 1995
  • Measurement of ocular blood flow velocity using colour Doppler imaging in low tension glaucoma.
  • Eye 1995, 9:29-33.
Reference Link
027

D. Broadway, I Grierson, C O’Brien, R Hitchings.

  • 1994
  • Adverse effects of topical anti-glaucoma medications. Part II. The outcome of filtration surgery.
  • Arch Ophthalmol 1994;112:1446-1454.
Reference Link
026

D Broadway, I Grierson, C O’Brien, RA Hitchings.

  • 1994
  • Adverse effects of topical anti-glaucoma medications. Part I. The conjunctival cell profile.
  • Arch Ophthalmol 1994;112:1437-1445.
Reference Link
025

C de Vivero, C O’Brien, L Lanigan, RA Hitchings.

  • 1994
  • Diurnal intraocular pressure variation in low tension glaucoma.
  • Eye 1994;8:521-523.
Reference Link
024

C O’Brien, D Clark.

  • 1994
  • Ocular biometry in preterm infants without retinopathy of prematurity.
  • Eye 1994;8:662-665.
Reference Link
023

M Austin, C O’Brien, P Wishart.

  • 1994
  • Flicker perimetry using a luminance threshold strategy at frequencies from 5-25Hz in glaucoma, ocular hypertension and normal controls.
  • Curr Eye Res 1994;13:7171-724.
Reference Link
022

DE Laws, R Haslett, D Ashby, C O’Brien, D Clark.

  • 1994
  • Axial length biometry in infants with retinopathy of prematurity.
  • Eye 1994;8:427-430.
Reference Link
021

C O’Brien, D Poinoosawmy, J Wu, R Hitchings.

  • 1994
  • Evaluation of a rapid thresholding program (Fastpac) in glaucoma.
  • Br J Ophthalmol 1994;78:516-9.
Reference Link
020

MW Austin, C O’Brien, PE Wishart.

  • 1994/1995
  • Forced choice flicker perimetry in glaucoma.
  • In: Perimetry Update 1994/1995; (eds) RP Mills, M Wall. Kugler Publ, Amsterdam, pp 135-140.
019

K. Evans, C O’Brien, A Patterson.

  • 1994
  • Corneal endothelial response to corticosteroid in cataract surgery.
  • Eur J Implant Refr Surg 1994;6:74-78.
Reference Link
018

B Moriarty, C O’Brien.

  • 1993
  • Cataract surgery in the glaucoma patient.
  • In: Ball S, Franklin R (eds); Trans New Orleans and Acad Ophthalmol - Glaucoma, Diagnosis and Therapy 1993. Kugler Publ, Amstelveen pp 159-168.
017

J. Singh, C O’Brien, M Wright.

  • 1993
  • Nebulised bronchodilator therapy causes acute angle closure glaucoma in predisposed individuals.
  • Resp Med 1993, 187:559-561
Reference Link
016

C O’Brien, JD Young, M Brown, C Short, M Bone.

  • 1993
  • Electrophysiology of type 2 mesangio-capillary glomerulonephritis with associated fundus abnormalities.
  • Br J Ophthalmol 1993;77:778-780.
reference Link
015

L Lanigan, C O’Brien, R Hitchings.

  • 1992
  • “Bubble sight”.
  • BMJ (Minerva) 1992;305:1588.
014

M Cox, C. O’Brien.

  • 1992
  • Comparison of computer assisted versus manual optic nerve head pallor measurement.
  • Invest Ophthalmol Vis Sci 1992;33:3169-3173.
Reference Link
013

D. Clark, C O’Brien, M Weindling, M Saed.

  • 1992
  • Initial experience of screening for retinopathy of prematurity.
  • Arch Dis Child 1992;67:1233-1236.
Reference Link
012

C. O’Brien, V Saxton, RP Crick, HB Meire.

  • 1992
  • Doppler carotid artery studies in asymmetric glaucoma.
  • Eye 1992;6:273-276
Reference Link
011

D. Poinoosawmy, J Sturmer, C O’Brien, J Wu, R Hitchings.

  • 1992
  • Is diffuse visual field loss in low tension glaucoma a prognostic indicator for progression.
  • In: Mills RP (ed). Perimetry Update 1992/93. Kugler Publ. Amsterdam, pp 121-127.
010

C O’Brien, M Austin, P Wareing, P Hammond.

  • 1992
  • Clinical evaluation of a new combined automated flicker and static perimeter.
  • In: Mills RP (ed). Perimetry Update 1992/93. Kugler Publ: Amsterdam, pp 603-606.
009

C O’Brien, B Schwartz.

  • 1992
  • Point by point linear regression analysis of automated visual fields in chronic open angle glaucoma.
  • In: Perimetry Update 1992/93; Mills RP (ed). Kugler Publ, Amsterdam, pp 149-152.
008

C. O’Brien, B Schwartz, T Takamoto.

  • 1991
  • Correlation of optic disc cupping, pallor and retinal nerve fibre layer thickness with visual field loss in chronic open angle glaucoma.
  • In: Perimetry Update 1991; eds Mills and Heijl: Kugler Publ, Amsterdam pp15-19.
Reference Link
007

C. O’Brien. Optic disc pallor measurement.

  • 1991
  • Optic disc pallor measurement.
  • Eye 1991;5:763.
Reference Link
006

J. Butcher, C. O’Brien.

  • 1991
  • The reproducibility of biometry and keratometry.
  • Eye 1991;5:708-711.
Reference Link
005

C. O’Brien, B Schwartz, T Takamoto, DC Wu.

  • 1991
  • Intraocular pressure and the rate of change of the visual field in chronic open angle glaucoma.
  • Am J Ophthalmol 1991;111:491-497.
Reference Link
004

McAllister, C. O’Brien. Neodymium:Yag transcleral cyclocoagulation: a clinical study.

  • 1990
  • Neodymium:Yag transcleral cyclocoagulation: a clinical study.
  • Eye 1990;4:651-654.
Reference Link
003

C. O’Brien, B Schwartz. The visual field in chronic open angle glaucoma:

  • 1990
  • The visual field in chronic open angle glaucoma: the rate of change in the different regions of the field.
  • Eye 1990;4:557-562.
Reference Link
002

CJ O’Brien, I Grierson, J McAllister. Treatment parameters for

  • 1990
  • transcleral cyclocoagulation with the Neodymium:Yag laser.
  • Lasers Ophthalmol 1990;3:221-225.
Reference Link
001

C J O’Brien, GM Kyle

  • 1988
  • Metastatic staphylococcus aureas endophthalmitis:
  • Br J Ophthalmol 1988;72:189-91.
Reference Link
Showing 1 - 177 out of 177
001

C J O’Brien, GM Kyle

  • 1988
  • Metastatic staphylococcus aureas endophthalmitis:
  • Br J Ophthalmol 1988;72:189-91.
Reference Link
002

CJ O’Brien, I Grierson, J McAllister. Treatment parameters for

  • 1990
  • transcleral cyclocoagulation with the Neodymium:Yag laser.
  • Lasers Ophthalmol 1990;3:221-225.
Reference Link
003

C. O’Brien, B Schwartz. The visual field in chronic open angle glaucoma:

  • 1990
  • The visual field in chronic open angle glaucoma: the rate of change in the different regions of the field.
  • Eye 1990;4:557-562.
Reference Link
004

McAllister, C. O’Brien. Neodymium:Yag transcleral cyclocoagulation: a clinical study.

  • 1990
  • Neodymium:Yag transcleral cyclocoagulation: a clinical study.
  • Eye 1990;4:651-654.
Reference Link
005

C. O’Brien, B Schwartz, T Takamoto, DC Wu.

  • 1991
  • Intraocular pressure and the rate of change of the visual field in chronic open angle glaucoma.
  • Am J Ophthalmol 1991;111:491-497.
Reference Link
006

J. Butcher, C. O’Brien.

  • 1991
  • The reproducibility of biometry and keratometry.
  • Eye 1991;5:708-711.
Reference Link
007

C. O’Brien. Optic disc pallor measurement.

  • 1991
  • Optic disc pallor measurement.
  • Eye 1991;5:763.
Reference Link
008

C. O’Brien, B Schwartz, T Takamoto.

  • 1991
  • Correlation of optic disc cupping, pallor and retinal nerve fibre layer thickness with visual field loss in chronic open angle glaucoma.
  • In: Perimetry Update 1991; eds Mills and Heijl: Kugler Publ, Amsterdam pp15-19.
Reference Link
009

C O’Brien, B Schwartz.

  • 1992
  • Point by point linear regression analysis of automated visual fields in chronic open angle glaucoma.
  • In: Perimetry Update 1992/93; Mills RP (ed). Kugler Publ, Amsterdam, pp 149-152.
010

C O’Brien, M Austin, P Wareing, P Hammond.

  • 1992
  • Clinical evaluation of a new combined automated flicker and static perimeter.
  • In: Mills RP (ed). Perimetry Update 1992/93. Kugler Publ: Amsterdam, pp 603-606.
011

D. Poinoosawmy, J Sturmer, C O’Brien, J Wu, R Hitchings.

  • 1992
  • Is diffuse visual field loss in low tension glaucoma a prognostic indicator for progression.
  • In: Mills RP (ed). Perimetry Update 1992/93. Kugler Publ. Amsterdam, pp 121-127.
012

C. O’Brien, V Saxton, RP Crick, HB Meire.

  • 1992
  • Doppler carotid artery studies in asymmetric glaucoma.
  • Eye 1992;6:273-276
Reference Link
013

D. Clark, C O’Brien, M Weindling, M Saed.

  • 1992
  • Initial experience of screening for retinopathy of prematurity.
  • Arch Dis Child 1992;67:1233-1236.
Reference Link
014

M Cox, C. O’Brien.

  • 1992
  • Comparison of computer assisted versus manual optic nerve head pallor measurement.
  • Invest Ophthalmol Vis Sci 1992;33:3169-3173.
Reference Link
015

L Lanigan, C O’Brien, R Hitchings.

  • 1992
  • “Bubble sight”.
  • BMJ (Minerva) 1992;305:1588.
016

C O’Brien, JD Young, M Brown, C Short, M Bone.

  • 1993
  • Electrophysiology of type 2 mesangio-capillary glomerulonephritis with associated fundus abnormalities.
  • Br J Ophthalmol 1993;77:778-780.
reference Link
017

J. Singh, C O’Brien, M Wright.

  • 1993
  • Nebulised bronchodilator therapy causes acute angle closure glaucoma in predisposed individuals.
  • Resp Med 1993, 187:559-561
Reference Link
018

B Moriarty, C O’Brien.

  • 1993
  • Cataract surgery in the glaucoma patient.
  • In: Ball S, Franklin R (eds); Trans New Orleans and Acad Ophthalmol - Glaucoma, Diagnosis and Therapy 1993. Kugler Publ, Amstelveen pp 159-168.
019

K. Evans, C O’Brien, A Patterson.

  • 1994
  • Corneal endothelial response to corticosteroid in cataract surgery.
  • Eur J Implant Refr Surg 1994;6:74-78.
Reference Link
020

MW Austin, C O’Brien, PE Wishart.

  • 1994/1995
  • Forced choice flicker perimetry in glaucoma.
  • In: Perimetry Update 1994/1995; (eds) RP Mills, M Wall. Kugler Publ, Amsterdam, pp 135-140.
021

C O’Brien, D Poinoosawmy, J Wu, R Hitchings.

  • 1994
  • Evaluation of a rapid thresholding program (Fastpac) in glaucoma.
  • Br J Ophthalmol 1994;78:516-9.
Reference Link
022

DE Laws, R Haslett, D Ashby, C O’Brien, D Clark.

  • 1994
  • Axial length biometry in infants with retinopathy of prematurity.
  • Eye 1994;8:427-430.
Reference Link
023

M Austin, C O’Brien, P Wishart.

  • 1994
  • Flicker perimetry using a luminance threshold strategy at frequencies from 5-25Hz in glaucoma, ocular hypertension and normal controls.
  • Curr Eye Res 1994;13:7171-724.
Reference Link
024

C O’Brien, D Clark.

  • 1994
  • Ocular biometry in preterm infants without retinopathy of prematurity.
  • Eye 1994;8:662-665.
Reference Link
025

C de Vivero, C O’Brien, L Lanigan, RA Hitchings.

  • 1994
  • Diurnal intraocular pressure variation in low tension glaucoma.
  • Eye 1994;8:521-523.
Reference Link
026

D Broadway, I Grierson, C O’Brien, RA Hitchings.

  • 1994
  • Adverse effects of topical anti-glaucoma medications. Part I. The conjunctival cell profile.
  • Arch Ophthalmol 1994;112:1437-1445.
Reference Link
027

D. Broadway, I Grierson, C O’Brien, R Hitchings.

  • 1994
  • Adverse effects of topical anti-glaucoma medications. Part II. The outcome of filtration surgery.
  • Arch Ophthalmol 1994;112:1446-1454.
Reference Link
028

Z Butt, G McKillop, C O’Brien, P Allan, P Aspinall.

  • 1995
  • Measurement of ocular blood flow velocity using colour Doppler imaging in low tension glaucoma.
  • Eye 1995, 9:29-33.
Reference Link
029

C O’Brien, J Wild.

  • 1995
  • Automated perimetry in glaucoma - room for improvement?
  • Br J Ophthalmol 1995;79:200-201. (editorial)
Reference Link
030

Z Butt, C O’Brien.

  • 1995
  • Reproducibility of pulsatile ocular blood flow measurements.
  • J Glaucoma 1995;4:214-218.
Reference Link
031

J Sing, H Chawla, C O’Brien.

  • 1995
  • Success rate and complications of intraoperative mitomycin-C in trabeculectomy surgery.
  • Eye 1995;9:460-466.
reference Link
032

A King, D David, H Jones, C O’Brien.

  • 1995
  • Non-attendance at an ophthalmic out-patient department.
  • J Roy Soc Med 1995;88:88-90.
Reference Link
033

GP Rao, C O’Brien, MH Dwyer, A Patterson.

  • 1995
  • Rapid onset bilateral calcific band keratopathy associated with phosphate containing steroid eye drops.
  • Eur J Implant Refr Surg 1995;7:251-252.
Reference Link
034

RS Anderson, P Detkova, C O’Brien.

  • 1995
  • Effect of temporal frequency and contrast on peripheral grating resolution.
  • Curr Eye Res 1995;14:1031-1033.
Reference Link
035

M Birch, S Barbosa, L Blumhardt, C O Brien, S Harding.

  • 1996
  • Retinal venous sheathing and the blood-retinal barrier in multiple sclerosis.
  • Arch Ophthalmol 1996;114-119.
Reference Link
036

RS Ayyala, C O’Brien, I Grierson, P Maltby.

  • 1996
  • Transcleral flow of aqueous humor: an in-vitro experiment.
  • Ophthalmol Surg 1996;27:66-69.
Reference Link
037

J Sing, R Bell, A Adams, C O’Brien,

  • 1996
  • Enhancement of post trabeculectomy bleb formation by laser suture lysis.
  • Br J Ophthalmol 1996;80:624-627.
Reference Link
038

C Lim, C O’Brien, N Bolton.

  • 1996
  • A simple clinical method to measure the optic disc size in glaucoma.
  • J Glaucoma 1996;5:241-245.
Reference Link
039

FD Ghanchi, TH Williamson, CS Lim, Z Butt, GM Baxter, G McKillop, C O’Brien.

  • 1996
  • Colour Doppler imaging in giant cell (temporal) arteritis: serial examination and comparison with non-arteritic anterior ischaemic optic neuropathy.
  • Eye 1996;10:459-464.
Reference Link
040

A Kosmin, M Austin, C.O’Brien, N. Cotu, P. Wishart.

  • 1996/1997
  • Ageing changes in automated perimetry. A comparison of flicker and luminance sensitivity in normal subjects.
  • In: Wall M, Heijl A (eds). Perimetry update 1996/1997. Kugler: Amsterdam, New York 1997, pp 229 - 233.
041

RWD Bell, C O’Brien.

  • 1997
  • Diagnostic outcome of hospital glaucoma referrals.
  • Ophthal Physiol Opt 1997;17:3-6.
Reference Link
042

RWD Bell, C O’Brien.

  • 1997
  • Accuracy of referral to a glaucoma clinic.
  • Ophthal Physiol Opt 1997;17:7-11.
Reference Link
043

C O’Brien, P Kelly, I Ritchie.

  • 1997
  • The effect of chronic inhibition of nitric oxide synthase on ocular blood flow and glucose metabolism in rats.
  • Br J Ophthalmol 1997;81:68-71.
Reference Link
044

Z Butt, C O’Brien, G McKillop, P Aspinall, P Allan.

  • 1997
  • Colour Doppler imaging in untreated high and normal pressure open angle glaucoma.
  • Invest Ophthalmol Vis Sci, 1997; 38: 690-6.
Reference Link
045

C O’Brien, Z Butt, C Ludlum.

  • 1997
  • Activation of the coagulation cascade in untreated primary open angle glaucoma.
  • Ophthalmol 1997; 104:725 - 730
Reference Link
046

RWD Bell, HK Yang, C O’Brien.

  • 1997
  • A case of bilateral cavernous hemangioma associated with intra-cerebral hemangioma.
  • Arch Ophthalmol 1997, 115:6, 818-9.
Reference Link
047

RS Anderson, C O’Brien.

  • 1997
  • Psychophysical evidence for selective loss of M ganglion cells in glaucoma
  • Vis Res 1997 , 37: 1079-1083.
Reference Link
048

RWD Bell, NE Habib, C O’Brien.

  • 1997
  • Long-term outcome and complications of trabeculectomy with a single per-operative application of 5-fluorouracil.
  • Eye 1997;11: 663-71.
Reference Link
049

JR Mackinnon, Z Butt, K Swa, C O’Brien.

  • 1997
  • Pulsatile ocular blood flow in untreated diabetic retinopathy.
  • Acta Ophthalmol, 1997; 75:6, 661-4.
Reference Link
050

C Buckley, P Hadoke, C O’Brien.

  • 1997
  • The use of isolated ocular arteries in-vitro to define the pathology of vascular changes in glaucoma.
  • Br J Ophthalmol 1997, 81:599 - 607
Reference Link
051

C. O’Brien.

  • 1998
  • Is there a role for computerised image analysis in glaucoma management.
  • Br. J Ophthalmol 1998, 82: 2-3. (Editorial).
Reference link
052

Kerr J, Nelson P, O’Brien C.

  • 1998
  • A comparison of ocular blood flow in untreated primary open-angle glaucoma and ocular hypertension.
  • Am J Ophthalmol 1998; 126: 42-51.
Reference link
053

O’Brien C

  • 1998
  • Vasospasm and glaucoma (Editorial).
  • Br J Ophthalmol 1998; 82: 855-6.
Reference link
054

Kelly PA, Buckley C, Ritchie IM, O’Brien C.

  • 1998
  • Possible role for nitric oxide releasing nerves in the regulation of ocular blood flow in the rat.
  • Br J Ophthalmol 1998; 82: 1199-202.
Reference Link
055

Fontana L, Poinoosawmy D, Bunce CV, O’Brien C, Hitchings RA.

  • 1998
  • Pulsatile ocular blood flow investigation in asymmetric normal-tension glaucoma and normal subjects.
  • Br J Ophthalmol 1998; 82: 731-6.
Reference Link
056

Buckley C H, Hadoke P, O’Brien C.

  • 1998
  • Role of the endothelium in modulating functional responses of isolated bovine anterior ciliary arteries to vasoconstrictor agonists.
  • Br J Ophthalmol 1998; 82: 826-829.
Reference Link
057

Edgar DF, Crabb DP, Rudnicka AR, Lawrensen JG, Gutteridge NM, O’Brien C.

  • 1999
  • Effects of dipivefrin and pilocarpine on pupil diameter, automated perimetry and Logmar acuity.
  • Graefe’s Arch Clin Exp Ophthalmol 1999; 237: 117-24.
Reference Link
058

Nelson P, Aspinall P, O’Brien C.

  • 1999
  • Patients’ perception of visual impairment in glaucoma. A pilot study.
  • Br J Ophthalmol 1999; 83: 546-552.
Reference Link
059

Henry E, Newby DE, Webb DJ, O’Brien C.

  • 1999
  • Peripheral endothelial dysfunction in normal pressure glaucoma.
  • Invest Ophthalmol Vis Sci 1999; 40: 1710-1714.
Reference Link
060

O’Brien C, Butt Z.

  • 1999
  • Blood flow velocity in the peripheral circulation of glaucoma patients.
  • Ophthalmologica 1999; 213: 150-153.
Reference Link
061

J Stokes, E Henry, C O’Brien.

  • 1998/1999
  • Differential Diagnosis of Normal Tension Glaucoma (1998)
  • In: Pillunat L, Harris A (eds) Fortbildurg Glaucoma. Enke Verlag, Stuggart, 1999.
062

King A, Bolton N, Aspinall P, O’Brien C.

  • 2000
  • Retinal nerve fibre layer volume in glaucoma.
  • Am J Ophthalmol 2000, 129: 599-607.
Reference Link
063

Stokes J, Andrew R, Seckyl J, O’Brien C.

  • 2000
  • Glucocorticoid and mineralocorticoid receptors and 11-beta-deyhydrogenase activity in rat and human ocular tissue.
  • Invest Ophthalmol Vis Sci 2000; 41: 1629-38.
Reference Link
064

McKinnon J, McKillop G, Swa K, O’Brien C, Butt Z, Nelson P.

  • 2000
  • Colour Doppler imaging of the ocular circulation in diabetic retinopathy.
  • Acta Ophthalmol, 2000, 78: 386-9.
Reference Link
065

Morgan-Davies J, King A, Aspinall P, O’Brien C.

  • 2000
  • Measurement of a novel optic disc topographic parameter ‘spikiness’ in glaucoma.
  • Graefe’s Arch Clin Exp Ophthalmol 2000, 238: 669- 76.
Reference Link
066

Devlin H, O’Brien C.

  • 2001
  • Normal tension glaucoma: Diagnosis and Management.
  • CME Journal Ophthalmol 2001; 5(1): 13-17.
067

O’Toole L, Cahill M, O’Brien C.

  • 2001
  • Eyelid hypertrichosis associated with latanoprost is reversible.
  • Eur J Ophthalmol. 2001 Oct-Dec;11(4):377-9.
Reference Link
068

Buckley C, Hadoke P, Henry E, O’Brien C.

  • 2002
  • Systemic vascular endothelial dysfunction in normal pressure glaucoma
  • Br J Ophthalmology 2002; 86; 227-32.
Reference Link
069

P Nelson, P Aspinall, C O’Brien.

  • 2003
  • The relationship between quality of life and visual function in glaucoma.
  • J Glaucoma 2003 Apr 12(2) 139-50.
Reference Link
070

S Quinn, C O’Brien, P McLoughlin.

  • 2003
  • Nitric oxide independent vasorelaxation in the bovine long posterior ciliary artery.
  • Eye 2003 July 17(5) 628-36.
Reference Link
071

J Kerr, C O’Brien.

  • 2003
  • Ocular blood flow in untreated ocular hypertension.
  • Am J Ophthalmology 2003 Dec 136(6) 1106-13.
Reference Link
072

J Stokes, R Best, C O’Brien, J Seckl.

  • 2003
  • Altered glucocorticoid peripheral sensitivity in glaucoma.
  • Invest Ophthal Vis Sci 2003; Dec 44(12) 5163-7.
Reference Link
073

R Kirwan, J Crean, C Fenerty, A Clark, C O’Brien.

  • 2004
  • Effect of cyclical mechanical stretch and exogenous transforming growth factor-B1 on matrix metalloproteinase-2 activity in lamina cribrosa cells from the human optic nerve head.
  • J Glaucoma 2004 Aug; 13(4): 327-34.
Reference Link
074

Morgan-Davies J, Taylor N, Hill AR, Aspinall P, O’Brien CJ, Asuara-Blanco A.

  • 2004
  • Three dimensional analysis of the lamina cribrosa in glaucoma.
  • Br J Ophthalmol 2004 Oct;88(10): 1299-304.
Reference Link
075

S L Ho, G F Dogar, J Wang, J Crean, Q D Wu, N Oliver, S Weitz, A Murray, P E Cleary, C O’Brien.

  • 2005
  • Elevated aqueous humour tissue inhibitor of matrix metalloproteinase-1 and connective tissue growth factor in pseudoexfoliation disease.
  • Br J Ophthalmol 2005;89:169-173.
Reference Link
076

C Cleary, C H Buckley, E Henry, P McLoughlin, C O’Brien, P W Hadoke.

  • 2005
  • Enhanced endothelium derived hyperpolarized factor activity in resistance arteries from normal pressure glaucoma patients: implications for vascular function in the eye.
  • Br J Ophthalmol 2005;89:223-228
Reference Link
077

T E Walshe, G Ferguson, P Connell, C O’Brien, P A Cahill.

  • 2005
  • Pulsatile flow increases the expression of eNOS, ET-1, and Prostacyclin in a novel in vitro coculture model of the retinal vasculature.
  • Invest Ophthal Vis Sci 2005;Jan(46)1:375-382.
Reference Link
078

P Aspinall, A Hill, P Nelson, C O’Brien, E O’Connell, L McCloughan, A Azuara-Blanco, R Brice, S Green, C Steeds.

  • 2005
  • Quality of life in patients with glaucoma: a conjoint analysis approach.
  • Visual Impairment Research 2005; 7 (1): 13-26.
Reference Link
079

VW Long, C O’Brien.

  • 2005
  • Trends in ophthalmic surgery in Ireland.
  • Irish Journal Med. Sci 2005; 174 (2); 36-39
Reference Link
080

R Kirwan, M O’Leonard, M Murphy A F Clark, C O’Brien

  • 2005
  • Transforming growth factor-beta-regulated gene transcription and protein expression in human GFAP-negative lamina cribrosa cells.
  • Glia. 2005 Dec;52(4):309-24.
Reference Link
081

R Kirwan, C Fenerty, J Crean, R Wordinger, A F Clark, C O’Brien

  • 2005
  • Influence of cyclical mechanical strain on extracellular matrix gene expression in human lamina cribrosa cells in vitro.
  • Mol Vis 2005 Sep 23;11:798-810
Reference Link
082

R Kane, L Stevenson, C Godson, A Stitt, C O’Brien.

  • 2005
  • Gremlin gene expression in bovine retinal pericytes exposed to elevated glucose.
  • Br J Ophthalmol 2005; Dec;89(12): 1638-42
Reference Link
083

A Knox, M Barry, C O’Brien.

  • 2006
  • The rising cost of glaucoma drugs in Ireland. 1996-2003.
  • Br J Ophthalmol 2006 Feb;90(2):162-5
Reference Link
084

McKernan DP, Caplis C, Donovan M, O’Brien C, Cotter T.

  • 2006
  • Age-dependent susceptibility of the retinal ganglion cell layer to cell death.
  • Invest Ophthalmol Vis Sci. 2006 Mar;47(3):807-14.
Reference Link
085

C Kelliher, D Kenny, C O’Brien.

  • 2006
  • Trends in blind registration in the adult population of the Republic of Ireland. 1996-2003.
  • Br J Ophthalmol 2006 Mar;90(3)367-71.
Reference Link
086

L Cryan, G Pidgeon, D Fitzgerald, C O’Brien.

  • 2006
  • COX-2 protects against thrombosis of the retinal vasculature in a mouse model of proliferative retinopathy.
  • Mol Vis. 2006 Apr 20;12:405-14
Reference Link
087

E Henry, D Newby, DJ Webb, PW Hadoke, C O’Brien.

  • 2006
  • Altered endothelin-1 vasoreactivity in patients with untreated normal-pressure glaucoma.
  • Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2528-32.
Reference Link
088

Y Delaney, T Walshe, C O’Brien.

  • 2006
  • Vasospasm in glaucoma: clinical and laboratory aspects.
  • Optom Vis Sci. 2006 Jul;83(7):406-14.
Reference Link
089

Guerin MB, McKernan DP, O’Brien CJ, Cotter TG.

  • 2006
  • Retinal ganglion cells: dying to survive.
  • Int J Dev Biol. 2006;50(8):665-74..
Reference Link
090

McKernan DP, Guerin MB, O’Brien CJ, Cotter TG. A key role for calpains in retinal ganglion cell death.

  • 2007
  • Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5420-30.
Reference Link
091

Lee H, O’Meara SJ, O’Brien C, Kane R.

  • 2007
  • The role of gremlin, a BMP antagonist, and epithelial-to-mesenchymal transition in proliferative vitreoretinopathy.
  • Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4291-9.
Reference Link
092

Connell P, Walshe T, Ferguson G, Gao W, O’Brien C, Cahill PA.

  • 2007
  • Elevated glucose attenuates agonist- and flow-stimulated endothelial nitric oxide synthase activity in microvascular retinal endothelial cells.
  • Endothelium. 2007 Jan-Feb;14(1):17-24.
Reference Link
093

Gao W, Ferguson G, Connell P, Walshe T, Murphy R, Birney YA, O’Brien C, Cahill PA.

  • 2007
  • High glucose concentrations alter hypoxia-induced control of vascular smooth muscle cell growth via a HIF-1alpha-dependent pathway.
  • J Mol Cell Cardiol. 2007 Mar;42(3):609-19. Epub 2006 Dec 21.
Reference Link
094

Horgan N, Kirwan RP, O’Brien CJ.

  • 2007
  • Choroidal detachment associated with latanoprost use in the fellow eye.
  • Ann Pharmacother. 2007 Jan;41(1):161-2.
Reference Link
095

Cryan LM, Paraoan L, Hiscott P, Damato BE, Grierson I, Gray D, Farrell M, Doherty GA, Fitzgerald DJ, O’Brien C.

  • 2008
  • Expression of COX-2 and prognostic outcome in uveal melanoma.
  • Curr Eye Res. 2008 Feb;33(2):177-84.
Reference Link
096

Aragon-Martin JA, Ritch R, Liebmann J, O’Brien C, Blaaow K, Mercieca F, Spiteri A, Cobb CJ, Damji KF, Tarkkanen A, Rezaie T, Child AH, Sarfarazi M.

  • 2008
  • Evaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma.
  • Mol Vis. 2008 Mar 17;14:533-41.
Reference Link
097

O’Driscoll C, O’Connor J, O’Brien CJ, Cotter TG.

  • 2008
  • Basic fibroblast growth factor-induced protection from light damage in the mouse retina in vivo.
  • J Neurochem. 2008 Apr;105(2):524-36. Epub 2007 Dec 13.
Reference Link
098

Kane R, Godson C, O’Brien C.

  • 2008
  • Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis.
  • Mol Vis. 2008 Jun 20;14:1138-48.
Reference Link
099

O’Connor JC, Wallace DM, O’Brien C, Cotter TG. A novel antioxidant function for the tumour suppressor gene p53 in the retinal ganglion cell.

  • 2008
  • A novel antioxidant function for the tumour suppressor gene p53 in the retinal ganglion cell.
  • Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4237-44
Reference Link
100

Morrow D, Guha S, Sweeney C, Birney Y, Walshe T, O’Brien C, Walls D, Redmond EM, Cahill PA.

  • 2008
  • Notch and vascular smooth muscle cell phenotype.
  • Circ Res. 2008 Dec 5;103(12):1370-82.
Reference Link
101

Cryan L, O’Brien C.

  • 2008
  • Proteomics as a research tool in clinical and experimental ophthalmology.
  • Proteomics Clin. App. 2008; 2(5); 762-75
Reference Link
102

Guerin M, Flynn T, Brady J, O’Brien C.

  • 2008
  • Worldwide geographical distribution of ophthalmic publications.
  • Int Ophthalmol; 2008; 29: 511-6.
Reference Link
103

Cryan L, Fitzgerald D, O’Brien C.

  • 2009
  • Ocular prostaglandin production and morphology in mice lacking a single isoform of cyclogenase.
  • Prostaglandins, Leuko & Essent Fatty Acids 2009 81:401-9.
Reference Link
104

Irnaten M, Barry RC, Quill B, Clark AF, Harvey BJ, O’Brien CJ.

  • 2009
  • Activation of stretch-activated channels and maxi-K+ channels by membrane stress of human lamina cribrosa cells.
  • Invest Ophthalmol Vis Sci. 2009 Jan;50(1):194-202. Epub 2008 Sep 4.
Reference Link
105

Kirwan RP, Wordinger RJ, Clark AF, O’Brien CJ.

  • 2009
  • Differential global and extra-cellular matrix focused gene expression patterns between normal and glaucomatous human lamina cribrosa cells.
  • Mol Vis. 2009;15:76-88. Epub 2009 Jan 15.
Reference Link
106

Quaranta L, Konstas AG, Rossetti L, Garcia-Feijoo J, O’Brien C, Nasr MB, Fogagnolo P, Demos CM, Stewart JA, Stewart WC.

  • 2010
  • Untreated 24-h intraocular pressures measured with Goldmann applanation tonometry vs nighttime supine pressures with Perkins applanation tonometry.
  • Eye (Lond). 2010 Jul;24(7):1252-8. Epub 2009 Dec 4.
Reference Link
107

Dervan EW, Chen H, Ho SL, Brummel N, Schmid J, Toomey D, Haralambova M, Gould E, Wallace DM, Prehn JH, O’Brien C, Murphy D.

  • 2010
  • Protein Macroarray Profiling of Serum Autoantibodies in Pseudoexfoliation Glaucoma.
  • Invest Ophthalmol Vis Sci. 2010 Jun;51(6):2968-75.
Reference Link
108

P O’Connor R, Cryan LM, Wynne K, de Stefani A, Fitzgerald D, O’Brien C, Cagney G.

  • 2010
  • Proteomics strategy for identifying candidate bioactive proteins in complex mixtures: application to the platelet releasate.
  • J Biomed Biotechnol. 2010; 2010:107859.
Reference Link
109

Walshe TE, Connell P, Cryan L, Ferguson G, O’Brien C, Cahill PA.

  • 2011
  • The role of pulsatile flow in controlling microvascular retinal endothelial and pericyte cell apoptosis and proliferation.
  • Cardiovasc Res. 2011 Feb 15;89(3):661-70.
Reference Link
110

Farrell SM, Groeger G, Bhatt L, Finnegan S, O’Brien CJ, Cotter TG.

  • 2011
  • bFGF-mediated redox activation of the PI3K/Akt pathway in retinal photoreceptor cells.
  • Eur J Neurosci. 2011 Feb;33(4):632-41.
Reference Link
111

Quill B, Docherty N, Clark AF, O’Brien CJ.

  • 2011
  • The Effect of Graded Cyclic Stretch on Extracellular Matrix Related Gene Expression Profiles in Cultured Primary Human Lamina Cribrosa Cells.
  • Invest Ophthalmol Vis Sci. 2011; Mar 30;52(3):1908-15.
Reference Link
112

Guerin M, Cotter T, McKernan D, O’Brien C.

  • 2011
  • Age Dependent Rat Retinal Ganglion Cell Susceptibility to Apoptotic Stimuli: Implications for Glaucoma.
  • Clin & Exper Ophthalmol Apr;39(3):243-51. 2011
Reference Link
113

McElnea EM, Quill B, Docherty NG, Irnaten M, Siah WF, Clark AF, O’Brien CJ, Wallace DM

  • 2011
  • Oxidative stress, mitochondrial dysfunction and calcium overload in human lamina cribrosa cells from glaucoma donors.
  • Mol Vis. 2011;17:1182-91.
Reference Link
114

Gallagher BA, Hart PM, O’Brien C, Stevenson MR, Jackson AJ.

  • 2011
  • Mobility and access to transport issues as experienced by people with vision impairment living in urban and rural Ireland.
  • Disabil Rehabil. 2011;33(12):979-88.
Reference Link
115

Browne JG, Ho SL, Kane R, Oliver N, Clark AF, O’Brien CJ, Crean JK.

  • 2011
  • Connective Tissue Growth Factor is increased in Pseudoexfoliation Glaucoma.
  • Invest Ophthalmol Vis Sci. 2011 Jun 1;52(6):3660-6
Reference Link
116

Walshe TE, Connell P, Cryan L, Ferguson G, Gardiner T, Morrow D, Redmond EM, O’Brien C, Cahill PA

  • 2011
  • Microvascular retinal endothelial and pericyte cell apoptosis in vitro: role of Hedgehog and Notch signaling.
  • Invest Ophthalmol Vis Sci. 2011 . Jun 23;52(7):4472-83.
Reference Link
117

Wiggs JL, Hewitt AW, Fan BJ, Wang DY, Figueiredo Sena DR, O’Brien C, Realini A, Craig JE, Dimasi DP, Mackey DA, Haines JL, Pasquale LR.

  • 2012
  • The p53 codon 72 PRO/PRO genotype may be associated with initial central visual field defects in caucasians with primary open angle glaucoma.
  • PLoS One. 2012;7(9):e45613. doi: 10.1371/journal.pone.0045613. Epub 2012 Sep 26
Reference Link
118

Kirwan RP, Felice L, Clark AF, O’Brien CJ, Leonard MO.

  • 2012
  • Hypoxia regulated gene transcription in human optic nerve lamina cribrosa cells in culture.
  • Invest Ophthalmol Vis Sci. 2012 53:2243-2255
Reference Link
119

Bhattacharya SK, Lee RK, Grus FH; 

  • 2013
  • Seventh ARVO/Pfizer Ophthalmics Research Institute Conference Working Group. Molecular biomarkers in glaucoma.
  • 2013 Jan 7;54(1):121-31
120

Igras E, Loughman J, Ratzlaff M, O’Caoimh R, O’Brien C.

  • 2013
  • Evidence of lower macular pigment optical density in chronic open angle glaucoma. Br J Ophthalmol. 2013 Aug;97(8):994-998
  • Br J Ophthalmol. 2013 Aug;97(8):994-998
Reference Link
121

Irnaten M, Barry RC, Wallace DM, Docherty NG, Quill B, Clark AF, O’Brien CJ.

  • 2013
  • Elevated maxi-K(+) ion channel current in glaucomatous lamina cribrosa cells
  • Exp Eye Res 2013 Oct; 115:224-9
Reference Link
122

Wallace DM, Clarke AF, Lipson KE, Andrews D, Crean JK, O’Brien CJ .

  • 2013
  • Anti-connective tissue growth factor antibody treatment reduces extracellular matrix production in trabecular meshwork and lamina cribrosa cells.
  • Invest Ophthalmol Vis Sci 2013 Dec 2;54(13)7836-48
Reference Link
123

Wallace DM, Murphy-Ullrich JE, Downs JC, O’Brien CJ

  • 2014
  • The role of matricellular proteins in glaucoma.
  • Matrix Biol 2014 Apr 12 pii S0945-053X(14)00058-4
Reference Link
124

McDonnell F, O’Brien C, Wallace D.

  • 2014
  • The role of epigenetics in the fibrotic processes associated with glaucoma.
  • J Ophthalmol. 2014~:750459.
Reference Link
125

Gao W, Ferguson G, Connell P, Walshe T, O’Brien C, Redmond EM, Cahill PA.

  • 2014
  • Glucose attenuates hypoxia-induced changes in endothelial cell growth by inhibiting HIF-1α expression.
  • Diab Vasc Dis Res. 2014 May 22;11(4):270-280.
Reference Link
126

Sundaresan P, Simpson DA, Sambare C, Duffy S, Lechner J, Dastane A, Dervan EW, Vallabh N, Chelerkar V, Deshpande M, O’Brien C, McKnight AJ, Willoughby CE

  • 2014
  • Whole-mitochondrial genome sequencing in primary open-angle glaucoma using massively parallel sequencing identifies novel and known pathogenic variants.
  • Genet Med. 2014 Sep 18.
Reference Link
127

McNally S,  O’Brien CJ. Metabolomics/Proteomics strategies used to identify biomarkers for exfoliation glaucoma. J Glaucoma. 2014 Oct-Nov;23(8 Suppl 1):S51-4.

  • 2014
  • Metabolomics/Proteomics strategies used to identify biomarkers for exfoliation glaucoma.
  • J Glaucoma. 2014 Oct-Nov;23(8 Suppl 1):S51-4.
Reference Link
128

McElnea EM, Hughes E, McGoldrick A, McCann A, Quill B, Docherty N, Irnaten M, Farrell M, Clark AF, O’Brien CJ, Wallace DM.

  • 2014
  • Lipofuscin accumulation and autophagy in glaucomatous human lamina cribrosa cells.
  • BMC Ophthalmol. 2014 Dec 2;14:153.
Reference Link
129

Quill B, Irnaten M, Docherty NG, McElnea EM, Wallace DM, Clark AF, O’Brien CJ

  • 2015
  • ‘Calcium channel blockade reduces mechanical strain induced extracellular matrix gene response in lamina cribrosa cells’.
  • Br J Ophthalmol. 2015 Mar 20. pii: bjophthalmol-2014-306093. doi: 10.1136/bjophthalmol-2014-306093. [Epub ahead of print]
Reference Link
130

Wallace DM, Pokrovskaya O, O’Brien CJ.

  • 2015
  • The function of matricellular proteins in the lamina cribrosa and trabecular meshwork in glaucoma.
  • J Ocul Pharmacol Ther. 2015 Apr 7. [Epub ahead of print]
Reference Link
131

Murphy RM, Bakir B, O’Brien C, Wiggs JL, Pasquale LR

  • 2015
  • Drug-induced Bilateral Secondary Angle-Closure Glaucoma: A Literature Synthesis.
  • J Glaucoma. 2015 Apr 21. [Epub ahead of print]
Reference Link
132

Wallace DM, Pokrovskaya O, O’Brien CJ.

  • 2015
  • The Function of Matricellular Proteins in the Lamina Cribrosa and Trabecular Meshwork in Glaucoma.
  • J Ocul Pharmacol Ther. 2015 Sep;31(7):386-95.
Reference Link
133

Siah WF, Loughman J, O’Brien C.

  • 2015
  • Lower Macular Pigment Optical Density in Foveal-Involved Glaucoma.
  • Ophthalmology. 2015 Oct;122(10):2029-37.
Reference Link
134

Quill B, Henry E, Simon E, O’Brien CJ.

  • 2015
  • Evaluation of the Effect of Hypercapnia on Vascular Function in Normal Tension Glaucoma.
  • Biomed Res Int. 2015;2015:418159.
Reference Link
135

Wallace DM, O’Brien CJ. The role of lamina cribrosa cells in optic nerve head fibrosis in glaucoma.

  • 2016
  • The role of lamina cribrosa cells in optic nerve head fibrosis in glaucoma.
  • Exp Eye Res. 2016 Jan;142:102-9.
Reference Link
136

O’Brien C, Clark AF.

  • 2016
  • Introduction to EER Special Issue on ocular fibrosis.
  • Exp Eye Res. 2016 Jan;142:1.
Reference Link
137

Murphy RM, Bakir B, O’Brien C, Wiggs JL, Pasquale LR.

  • 2016
  • Drug-induced Bilateral Secondary Angle-Closure Glaucoma: A Literature Synthesis.
  • J Glaucoma. 2016 Feb;25(2):e99-e105.
Reference Link
138

Pokrovskaya O, O’Brien C.

  • 2016
  • What's in a Gene? Pseudoexfoliation Syndrome and Pigment Dispersion Syndrome in the Same Patient.
  • Case Rep Ophthalmol. 2016 Jan 21;7(1):54-60. doi: 10.1159/000443697. eCollection 2016 Jan 21.
Reference Link
139

McDonnell F, Irnaten M, Clark AF, O’Brien CJ, Wallace DM.

  • 2016
  • Hypoxia-Induced Changes in DNA Methylation Alter RASAL1 and TGFβ1 Expression in Human Trabecular Meshwork Cells.
  • PLoS One. 2016 Apr 28;11(4):e0153354. doi: 10.1371/journal.pone.0153354. eCollection 2016 Apr 28.
Reference Link
140

Treacy MP, O’Neill EC, Murphy M, O’Toole L, Delaney Y, O’Brien C, Connell PP.

  • 2016
  • Opportunistic detection of glaucomatous optic discs within a diabetic retinopathy screening service.
  • Eur J Ophthalmol. 2016 Jun 10;26(4):315-20. doi: 10.5301/ejo.5000722. Epub 2015 Dec 17.
Reference Link
141

Paula JS, O’Brien C, Stamer WD.

  • 2016
  • Life under pressure: The role of ocular cribriform cells in preventing glaucoma.
  • Exp Eye Res. 2016 Oct;151:150-9. doi: 10.1016/j.exer.2016.08.014. Epub 2016 Aug 25. Review.
Reference Link
142

McDonnell FS, McNally SA, Clark AF, O’Brien CJ, Wallace DM.

  • 2016
  • Increased Global DNA Methylation and Decreased TGFβ1 Promoter Methylation in Glaucomatous Lamina Cribrosa Cells.
  • J Glaucoma. 2016 Oct;25(10):e834-e842.
Reference Link
143

Murphy ML, Pokrovskaya O, Galligan M, O’Brien C.

  • 2017
  • Corneal hysteresis in patients with glaucoma-like optic discs, ocular hypertension and glaucoma.
  • BMC Ophthalmol. 2017 Jan 10;17(1):1. doi: 10.1186/s12886-016-0396-9.
Reference Link
144

O’Callaghan J, Crosbie DE, Cassidy PS, Sherwood JM, Flügel-Koch C, Lütjen-Drecoll E, Humphries MM, Reina-Torres E, Wallace D, Kiang AS, Campbell M, Daniel SW, Overby DR, O’Brien C, Tam LC, Humphries P.

  • 2017
  • Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma.
  • Hum Mol Genet. 2017 Feb 1. doi: 10.1093/hmg/ddx028.
Reference Link
145

Wallace DM, Pokrovskaya O, O’Brien CJ.

  • 2015
  • The Function of Matricellular Proteins in the Lamina Cribrosa and Trabecular Meshwork in Glaucoma.
  • J Ocul Pharmacol Ther. 2015 Sep;31(7):386-95. doi: 10.1089/jop.2014.0163. Epub 2015 Apr 7. Review.
Reference Link
146

Barrett C, O’Brien C, Butler JS, Loughman J.

  • 2017
  • Barriers to glaucoma case finding as perceived by optometrists in Ireland.
  • Clin Exp Optom. 2017 Jul 17. doi: 10.1111/cxo.12573.
Reference Link
147

Liu B, McNally S, Kilpatrick JI, Jarvis SP, O’Brien CJ.

  • 2017
  • Aging and ocular tissue stiffness in glaucoma.
  • Surv Ophthalmol. 2017 Jun 27. pii: S0039-6257(15)30018-7. doi: 10.1016/j.survophthal.2017.06.007
Reference Link
148

Kamel K, Farrell M, O’Brien C.

  • 2017
  • Mitochondrial dysfunction in ocular disease: Focus on glaucoma.
  • Mitochondrion. 2017 Jul;35:44-53. doi: 10.1016/j.mito.2017.05.004. Epub 2017 May 9.
Reference Link
149

Siah WF, O’Brien C, Loughman JJ.

  • 2017
  • Macular pigment is associated with glare-affected visual function and central visual field loss in glaucoma.
  • Br J Ophthalmol. 2017 Oct 5. pii: bjophthalmol-2017-310215. doi: 10.1136/bjophthalmol-2017-310215. [Epub ahead of print]
Reference Link
150

Liu B, Kilpatrick JI, Lukasz B, Jarvis SP, McDonnell F, Wallace DM, Clark AF, O’Brien CJ.

  • 2018
  • Increased Substrate Stiffness Elicits a Myofibroblastic Phenotype in Human Lamina Cribrosa Cells.
  • Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):803-814. doi: 1
Reference Link
151

Irnaten M, Zhdanov A, Brennan D, Crotty T, Clark A, Papkovsky D, O’Brien C.

  • 2018
  • Activation of the NFAT-Calcium Signaling Pathway in Human Lamina Cribrosa Cells in Glaucoma.
  • Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):831-842. doi: 10.1167/iovs.17-22531.
Reference Link
152

Barrett C, O’Brien C, Loughman J.

  • 2018
  • Glaucoma referral refinement in Ireland: managing the sensitivity-specificity paradox in optometric practice.
  • Ophthalmic Physiol Opt. 2018 Feb 28. doi: 10.1111/opo.12446
Reference Link
153

Kamel K, Falzan K, Dervan E, O’Brien C.

  • 2018
  • Difference in intraocular pressure measurements between non-contact tonometry and Goldman applanation tonometry
  • Ir J Med Sci. 2018
Reference Link
154

Kamel K, Bourke L, O’Brien C.

  • 2018
  • Clinical and Laboratory Biomarkers for Pseudoexfoliation Syndrome.
  • J Glaucoma. 2018 Jul;27 Suppl 1:S111-S113.
Reference Link
155

Loskutova E, O’Brien C, Loskutov I, Loughman J.

  • 2018
  • Nutritional supplementation in the treatment of glaucoma: A systematic review.
  • Surv Ophthalmol. 2018 Oct 6. pii: S0039-6257(18)30100-0.
Reference Link
156

Andrews D, Oliviero G, De Chiara L, Watson A, Rochford E, Wynne K, Kennedy C, Clerkin S, Doyle B, Godson C, Connell P, O’Brien C, Cagney G, Crean J.

  • 2019
  • Unravelling the transcriptional responses of TGF-β: Smad3 and EZH2 constitute a regulatory switch that controls neuroretinal epithelial cell fate specification.
  • FASEB J. 2019 May;33(5):6667-6681. doi: 10.1096/fj.201800566RR
Reference Link
157

Bourke CM, Loughman J, Fltcroft DI, Loskutova E, O’Brien C.

  • 2019
  • We can't afford to turn a blind eye to myopia.
  • QJM. 2019 Mar 26. pii: hcz076. doi: 10.1093/qjmed/hcz076.
Reference Link
158

Murtagh P, Greene G, O’Brien C.

  • 2020
  • Current application of machine learning in the screening and diagnosis of glaucoma: a systematic review and Meta-analysis.
  • Int J Ophthalmic. 2020 Jan18;13(1):149-162
Reference Link
159

Greene AG, Eivers SB, Dervan EWJ,O’Brien CJ, Wallace DM.

  • 2020
  • Lysyl Oxidase Like 1: Biological roles and regulation.
  • Exp Eye Res. 2020 Apr;193107975. doi:10.1016/j.exer.2020.107975. Epub 2020 Feb15.
Reference Link
160

Iraten M, O’Malley G, Clark AF, O’Brien CJ.

  • 2020
  • Transient receptor potential channels TRPC1/TRPC6 regulate lamina cribrosa cell extracellular matrix gene transcription and proliferation.
  • Exp Eye Res. 2020 Apr;193:107980. doi: 10.1016/j.exer.2020.107980. Epub 2020 Feb 20.
Reference Link
161

Eivers SB, Greene AG, Dervan E, O’Brien C, Wallace D

  • 2020
  • Prevalence of Pseudoexfoliation Glaucoma Risk-associated Variants Within Lysyl Oxidase-like 1 in an Irish Population.
  • J Glaucoma. 2020 Jun;29(6):417-422. doi:10.1097/IJG.0000000000001475.
Reference Link
162

Rahman N, O’Neill E, Irnaten M, Wallace D, O’Brien C.

  • 2020
  • Corneal Stiffness and Collagen Cross-Linking Proteins in Glaucoma: Potential for Novel Therapeutic Strategy.
  • J Ocul Pharmacol Ther. 2020 Jul 13. doi: 10.1089/jop.2019.0118.
Reference Link
163

Hopkins AA, Murphy R, Irnaten M, Wallace DM, Quill B, O’Brien C.

  • 2020
  • The Role of Lamina Cribrosa Tissue Stiffness and Fibrosis as Fundamental Biomechanical Drivers of Pathological Glaucomatous Cupping.
  • Am J Physiol Cell Physiol. 2020 Jul 15. doi: 10.1152/ajpcell.00054.2020.
Reference Link
164

Kamel K, O’Brien CJ, Zhdanov AV, Papkovsky DB, Clark AF, Stamer WD, Irnaten M.

  • 2020
  • Reduced Oxidative Phosphorylation and Increased Glycolysis in Human Glaucoma Lamina Cribrosa Cells.
  • Invest Ophthalmol Vis Sci. 2020 Nov 2;61(13):4. doi: 10.1167/iovs.61.13.4.
Reference Link
165

Irnaten M, Duff A, Clark A, O’Brien C.

  • 2020
  • Intra-Cellular Calcium Signaling Pathways (PKC, RAS/RAF/MAPK, PI3K) in Lamina Cribrosa Cells in Glaucoma.
  • J Clin Med. 2020 Dec 26;10(1):62. doi: 10.3390/jcm10010062.
Reference Link
166

Greene AG, Eivers SB, McDonnell F, Dervan EWJ, O’Brien CJ, Wallace DM.

  • 2020
  • Differential Lysyl oxidase like 1 expression in pseudoexfoliation glaucoma is orchestrated via DNA methylation.
  • Exp Eye Res. 2020 Dec;201:108349. doi: 10.1016/j.exer.2020.108349. Epub 2020
Reference Link
167

Cassidy PS, Kelly RA, Reina-Torres E, Sherwood JM, Humphries MM, Kiang AS, Farrar GJ, O’Brien C, Campbell M, Stamer WD, Overby DR, Humphries P, O’Callaghan J.

  • 2020
  • siRNA targeting Schlemm's canal endothelial tight junctions enhances outflow facility and reduces IOP in a steroid-induced OHT rodent model.
  • Mol Ther Methods Clin Dev. 2020 Oct 31;20:86-94. doi: 10.1016/j.omtm.2020.10.022. eCollection 2021 Mar 12.
Reference Link
168

Kamel K, Dervan E, Falzon K, O’Brien C.

  • 2020
  • Difference in intraocular pressure measurements between non-contact tonometry and Goldmann applanation tonometry and the role of central corneal thickness in affecting glaucoma referrals.
  • Ir J Med Sci. 2019 Feb;188(1):321-325. doi: 10.1007/s11845-018-1795-0. Epub 2018 Apr 4.
Reference Link
169

Doolan E, O’Brien C.

  • 2021
  • Abnormal corneal properties in osteogenesis imperfect and glaucoma: a case series.
  • BMJ Open Ophthalmic. 2021 Apr15;6(1):e000684 doi: 10.1136/bmjophth-2020-000684. eCollection 2021.
Reference Link
170

O’Regan A, O’Brien CJ, Eivers SB.

  • 2021
  • The lysophosphatidic acid axis in fibrosis: Implications for glaucoma.
  • Wound Repair Regen. 2021 Jul;29(4):613-626. doi: 10.1111/wrr.12929. Epub 2021 May 19.
Reference Link
171

Hurley DJ, Iranaten, O’Brien C.

  • 2021
  • Metformin and Glaucoma-Review of Anti-Fibrotic Processes and Bioenergetics.
  • Cells 2021 Aug 19;10(8):2131. Doi: 10.3390/cells10082131.
Reference Link
172

Kelly RA, Perkumas KM, Campbell M, Farrar GJ, Stamer WD, Humphries P, O’Callaghan J, O’Brien CJ.

  • 2021
  • Fibrotic Changes to Schlemm’s Canal Endothelial Cells in Glaucoma.
  • Int J Mol Sci. 2021 Aug 31;22(17):9446. Doi 10.3390/ijms22179446.
Reference Link
173

Murphy R, Irnaten M, Hopkins A, O Callaghan J, Stamer WD, Clark AF, Wallace D, O’Brien CJ.

  • 2022
  • Matrix Mechanotransduction via Yes-Associated Protein in Human Lamina Cribosa Cells in Glaucoma.
  • Invest Ophthalmol Vis Sci. 2022 Jan 3;63(1):16 doi: 10.1167/iovs.63.1.16.
Reference Link
174

Powell S, Doolan E, Curtin K, Doyle A, O’Brien C.

  • 2022
  • Audit of outcomes following attendance at the City West drive-through IOP glaucoma clinic during COVID-19 pandemic.
  • Ir J Med Sci. 2022 Jan 16:1-10. doi: 10.1007/s11845-021-02893-9.
Reference Link
175

Powell S, Irnaten M, O’Brien C.

  • 2022
  • Glaucoma – A Stiff Eye in a Stiff Body
  • Curr Eye Res. 2022 Mar 7:1-9. doi: 10.1080/02713683.2022.2039204.
reference Link
176

Hurley DJ, Normile C, Irnaten M, O’Brien C.

  • 2022
  • The Intertwined Roles of Oxidative Stress and Endoplasmic Reticulum Stress in Glaucoma.
  • Antioxidants (Basel). 2022 Apr 29;11(5):886. doi: 10.3390/antiox11050886
reference Link
177

Murtagh P, O’Brien C.

  • 2022
  • Corneal Hysteresis, Intraocular Pressure and Progression of Glaucoma: Time for a “Hyst-Oric” Change in Clinical Practice?
  • J Clin Med. 2022 May 20;11(10):2895. doi: 10.3390/jcm11102895
Reference Link
Showing 1 - 177 out of 177
177

Murtagh P, O’Brien C.

  • 2022
  • Corneal Hysteresis, Intraocular Pressure and Progression of Glaucoma: Time for a “Hyst-Oric” Change in Clinical Practice?
  • J Clin Med. 2022 May 20;11(10):2895. doi: 10.3390/jcm11102895
Reference Link
176

Hurley DJ, Normile C, Irnaten M, O’Brien C.

  • 2022
  • The Intertwined Roles of Oxidative Stress and Endoplasmic Reticulum Stress in Glaucoma.
  • Antioxidants (Basel). 2022 Apr 29;11(5):886. doi: 10.3390/antiox11050886
reference Link
175

Powell S, Irnaten M, O’Brien C.

  • 2022
  • Glaucoma – A Stiff Eye in a Stiff Body
  • Curr Eye Res. 2022 Mar 7:1-9. doi: 10.1080/02713683.2022.2039204.
reference Link
174

Powell S, Doolan E, Curtin K, Doyle A, O’Brien C.

  • 2022
  • Audit of outcomes following attendance at the City West drive-through IOP glaucoma clinic during COVID-19 pandemic.
  • Ir J Med Sci. 2022 Jan 16:1-10. doi: 10.1007/s11845-021-02893-9.
Reference Link
173

Murphy R, Irnaten M, Hopkins A, O Callaghan J, Stamer WD, Clark AF, Wallace D, O’Brien CJ.

  • 2022
  • Matrix Mechanotransduction via Yes-Associated Protein in Human Lamina Cribosa Cells in Glaucoma.
  • Invest Ophthalmol Vis Sci. 2022 Jan 3;63(1):16 doi: 10.1167/iovs.63.1.16.
Reference Link
172

Kelly RA, Perkumas KM, Campbell M, Farrar GJ, Stamer WD, Humphries P, O’Callaghan J, O’Brien CJ.

  • 2021
  • Fibrotic Changes to Schlemm’s Canal Endothelial Cells in Glaucoma.
  • Int J Mol Sci. 2021 Aug 31;22(17):9446. Doi 10.3390/ijms22179446.
Reference Link
171

Hurley DJ, Iranaten, O’Brien C.

  • 2021
  • Metformin and Glaucoma-Review of Anti-Fibrotic Processes and Bioenergetics.
  • Cells 2021 Aug 19;10(8):2131. Doi: 10.3390/cells10082131.
Reference Link
170

O’Regan A, O’Brien CJ, Eivers SB.

  • 2021
  • The lysophosphatidic acid axis in fibrosis: Implications for glaucoma.
  • Wound Repair Regen. 2021 Jul;29(4):613-626. doi: 10.1111/wrr.12929. Epub 2021 May 19.
Reference Link
169

Doolan E, O’Brien C.

  • 2021
  • Abnormal corneal properties in osteogenesis imperfect and glaucoma: a case series.
  • BMJ Open Ophthalmic. 2021 Apr15;6(1):e000684 doi: 10.1136/bmjophth-2020-000684. eCollection 2021.
Reference Link
168

Kamel K, Dervan E, Falzon K, O’Brien C.

  • 2020
  • Difference in intraocular pressure measurements between non-contact tonometry and Goldmann applanation tonometry and the role of central corneal thickness in affecting glaucoma referrals.
  • Ir J Med Sci. 2019 Feb;188(1):321-325. doi: 10.1007/s11845-018-1795-0. Epub 2018 Apr 4.
Reference Link
167

Cassidy PS, Kelly RA, Reina-Torres E, Sherwood JM, Humphries MM, Kiang AS, Farrar GJ, O’Brien C, Campbell M, Stamer WD, Overby DR, Humphries P, O’Callaghan J.

  • 2020
  • siRNA targeting Schlemm's canal endothelial tight junctions enhances outflow facility and reduces IOP in a steroid-induced OHT rodent model.
  • Mol Ther Methods Clin Dev. 2020 Oct 31;20:86-94. doi: 10.1016/j.omtm.2020.10.022. eCollection 2021 Mar 12.
Reference Link
166

Greene AG, Eivers SB, McDonnell F, Dervan EWJ, O’Brien CJ, Wallace DM.

  • 2020
  • Differential Lysyl oxidase like 1 expression in pseudoexfoliation glaucoma is orchestrated via DNA methylation.
  • Exp Eye Res. 2020 Dec;201:108349. doi: 10.1016/j.exer.2020.108349. Epub 2020
Reference Link
165

Irnaten M, Duff A, Clark A, O’Brien C.

  • 2020
  • Intra-Cellular Calcium Signaling Pathways (PKC, RAS/RAF/MAPK, PI3K) in Lamina Cribrosa Cells in Glaucoma.
  • J Clin Med. 2020 Dec 26;10(1):62. doi: 10.3390/jcm10010062.
Reference Link
164

Kamel K, O’Brien CJ, Zhdanov AV, Papkovsky DB, Clark AF, Stamer WD, Irnaten M.

  • 2020
  • Reduced Oxidative Phosphorylation and Increased Glycolysis in Human Glaucoma Lamina Cribrosa Cells.
  • Invest Ophthalmol Vis Sci. 2020 Nov 2;61(13):4. doi: 10.1167/iovs.61.13.4.
Reference Link
163

Hopkins AA, Murphy R, Irnaten M, Wallace DM, Quill B, O’Brien C.

  • 2020
  • The Role of Lamina Cribrosa Tissue Stiffness and Fibrosis as Fundamental Biomechanical Drivers of Pathological Glaucomatous Cupping.
  • Am J Physiol Cell Physiol. 2020 Jul 15. doi: 10.1152/ajpcell.00054.2020.
Reference Link
162

Rahman N, O’Neill E, Irnaten M, Wallace D, O’Brien C.

  • 2020
  • Corneal Stiffness and Collagen Cross-Linking Proteins in Glaucoma: Potential for Novel Therapeutic Strategy.
  • J Ocul Pharmacol Ther. 2020 Jul 13. doi: 10.1089/jop.2019.0118.
Reference Link
161

Eivers SB, Greene AG, Dervan E, O’Brien C, Wallace D

  • 2020
  • Prevalence of Pseudoexfoliation Glaucoma Risk-associated Variants Within Lysyl Oxidase-like 1 in an Irish Population.
  • J Glaucoma. 2020 Jun;29(6):417-422. doi:10.1097/IJG.0000000000001475.
Reference Link
160

Iraten M, O’Malley G, Clark AF, O’Brien CJ.

  • 2020
  • Transient receptor potential channels TRPC1/TRPC6 regulate lamina cribrosa cell extracellular matrix gene transcription and proliferation.
  • Exp Eye Res. 2020 Apr;193:107980. doi: 10.1016/j.exer.2020.107980. Epub 2020 Feb 20.
Reference Link
159

Greene AG, Eivers SB, Dervan EWJ,O’Brien CJ, Wallace DM.

  • 2020
  • Lysyl Oxidase Like 1: Biological roles and regulation.
  • Exp Eye Res. 2020 Apr;193107975. doi:10.1016/j.exer.2020.107975. Epub 2020 Feb15.
Reference Link
158

Murtagh P, Greene G, O’Brien C.

  • 2020
  • Current application of machine learning in the screening and diagnosis of glaucoma: a systematic review and Meta-analysis.
  • Int J Ophthalmic. 2020 Jan18;13(1):149-162
Reference Link
157

Bourke CM, Loughman J, Fltcroft DI, Loskutova E, O’Brien C.

  • 2019
  • We can't afford to turn a blind eye to myopia.
  • QJM. 2019 Mar 26. pii: hcz076. doi: 10.1093/qjmed/hcz076.
Reference Link
156

Andrews D, Oliviero G, De Chiara L, Watson A, Rochford E, Wynne K, Kennedy C, Clerkin S, Doyle B, Godson C, Connell P, O’Brien C, Cagney G, Crean J.

  • 2019
  • Unravelling the transcriptional responses of TGF-β: Smad3 and EZH2 constitute a regulatory switch that controls neuroretinal epithelial cell fate specification.
  • FASEB J. 2019 May;33(5):6667-6681. doi: 10.1096/fj.201800566RR
Reference Link
155

Loskutova E, O’Brien C, Loskutov I, Loughman J.

  • 2018
  • Nutritional supplementation in the treatment of glaucoma: A systematic review.
  • Surv Ophthalmol. 2018 Oct 6. pii: S0039-6257(18)30100-0.
Reference Link
154

Kamel K, Bourke L, O’Brien C.

  • 2018
  • Clinical and Laboratory Biomarkers for Pseudoexfoliation Syndrome.
  • J Glaucoma. 2018 Jul;27 Suppl 1:S111-S113.
Reference Link
153

Kamel K, Falzan K, Dervan E, O’Brien C.

  • 2018
  • Difference in intraocular pressure measurements between non-contact tonometry and Goldman applanation tonometry
  • Ir J Med Sci. 2018
Reference Link
152

Barrett C, O’Brien C, Loughman J.

  • 2018
  • Glaucoma referral refinement in Ireland: managing the sensitivity-specificity paradox in optometric practice.
  • Ophthalmic Physiol Opt. 2018 Feb 28. doi: 10.1111/opo.12446
Reference Link
151

Irnaten M, Zhdanov A, Brennan D, Crotty T, Clark A, Papkovsky D, O’Brien C.

  • 2018
  • Activation of the NFAT-Calcium Signaling Pathway in Human Lamina Cribrosa Cells in Glaucoma.
  • Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):831-842. doi: 10.1167/iovs.17-22531.
Reference Link
150

Liu B, Kilpatrick JI, Lukasz B, Jarvis SP, McDonnell F, Wallace DM, Clark AF, O’Brien CJ.

  • 2018
  • Increased Substrate Stiffness Elicits a Myofibroblastic Phenotype in Human Lamina Cribrosa Cells.
  • Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):803-814. doi: 1
Reference Link
149

Siah WF, O’Brien C, Loughman JJ.

  • 2017
  • Macular pigment is associated with glare-affected visual function and central visual field loss in glaucoma.
  • Br J Ophthalmol. 2017 Oct 5. pii: bjophthalmol-2017-310215. doi: 10.1136/bjophthalmol-2017-310215. [Epub ahead of print]
Reference Link
148

Kamel K, Farrell M, O’Brien C.

  • 2017
  • Mitochondrial dysfunction in ocular disease: Focus on glaucoma.
  • Mitochondrion. 2017 Jul;35:44-53. doi: 10.1016/j.mito.2017.05.004. Epub 2017 May 9.
Reference Link
147

Liu B, McNally S, Kilpatrick JI, Jarvis SP, O’Brien CJ.

  • 2017
  • Aging and ocular tissue stiffness in glaucoma.
  • Surv Ophthalmol. 2017 Jun 27. pii: S0039-6257(15)30018-7. doi: 10.1016/j.survophthal.2017.06.007
Reference Link
146

Barrett C, O’Brien C, Butler JS, Loughman J.

  • 2017
  • Barriers to glaucoma case finding as perceived by optometrists in Ireland.
  • Clin Exp Optom. 2017 Jul 17. doi: 10.1111/cxo.12573.
Reference Link
145

Wallace DM, Pokrovskaya O, O’Brien CJ.

  • 2015
  • The Function of Matricellular Proteins in the Lamina Cribrosa and Trabecular Meshwork in Glaucoma.
  • J Ocul Pharmacol Ther. 2015 Sep;31(7):386-95. doi: 10.1089/jop.2014.0163. Epub 2015 Apr 7. Review.
Reference Link
144

O’Callaghan J, Crosbie DE, Cassidy PS, Sherwood JM, Flügel-Koch C, Lütjen-Drecoll E, Humphries MM, Reina-Torres E, Wallace D, Kiang AS, Campbell M, Daniel SW, Overby DR, O’Brien C, Tam LC, Humphries P.

  • 2017
  • Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma.
  • Hum Mol Genet. 2017 Feb 1. doi: 10.1093/hmg/ddx028.
Reference Link
143

Murphy ML, Pokrovskaya O, Galligan M, O’Brien C.

  • 2017
  • Corneal hysteresis in patients with glaucoma-like optic discs, ocular hypertension and glaucoma.
  • BMC Ophthalmol. 2017 Jan 10;17(1):1. doi: 10.1186/s12886-016-0396-9.
Reference Link
142

McDonnell FS, McNally SA, Clark AF, O’Brien CJ, Wallace DM.

  • 2016
  • Increased Global DNA Methylation and Decreased TGFβ1 Promoter Methylation in Glaucomatous Lamina Cribrosa Cells.
  • J Glaucoma. 2016 Oct;25(10):e834-e842.
Reference Link
141

Paula JS, O’Brien C, Stamer WD.

  • 2016
  • Life under pressure: The role of ocular cribriform cells in preventing glaucoma.
  • Exp Eye Res. 2016 Oct;151:150-9. doi: 10.1016/j.exer.2016.08.014. Epub 2016 Aug 25. Review.
Reference Link
140

Treacy MP, O’Neill EC, Murphy M, O’Toole L, Delaney Y, O’Brien C, Connell PP.

  • 2016
  • Opportunistic detection of glaucomatous optic discs within a diabetic retinopathy screening service.
  • Eur J Ophthalmol. 2016 Jun 10;26(4):315-20. doi: 10.5301/ejo.5000722. Epub 2015 Dec 17.
Reference Link
139

McDonnell F, Irnaten M, Clark AF, O’Brien CJ, Wallace DM.

  • 2016
  • Hypoxia-Induced Changes in DNA Methylation Alter RASAL1 and TGFβ1 Expression in Human Trabecular Meshwork Cells.
  • PLoS One. 2016 Apr 28;11(4):e0153354. doi: 10.1371/journal.pone.0153354. eCollection 2016 Apr 28.
Reference Link
138

Pokrovskaya O, O’Brien C.

  • 2016
  • What's in a Gene? Pseudoexfoliation Syndrome and Pigment Dispersion Syndrome in the Same Patient.
  • Case Rep Ophthalmol. 2016 Jan 21;7(1):54-60. doi: 10.1159/000443697. eCollection 2016 Jan 21.
Reference Link
137

Murphy RM, Bakir B, O’Brien C, Wiggs JL, Pasquale LR.

  • 2016
  • Drug-induced Bilateral Secondary Angle-Closure Glaucoma: A Literature Synthesis.
  • J Glaucoma. 2016 Feb;25(2):e99-e105.
Reference Link
136

O’Brien C, Clark AF.

  • 2016
  • Introduction to EER Special Issue on ocular fibrosis.
  • Exp Eye Res. 2016 Jan;142:1.
Reference Link
135

Wallace DM, O’Brien CJ. The role of lamina cribrosa cells in optic nerve head fibrosis in glaucoma.

  • 2016
  • The role of lamina cribrosa cells in optic nerve head fibrosis in glaucoma.
  • Exp Eye Res. 2016 Jan;142:102-9.
Reference Link
134

Quill B, Henry E, Simon E, O’Brien CJ.

  • 2015
  • Evaluation of the Effect of Hypercapnia on Vascular Function in Normal Tension Glaucoma.
  • Biomed Res Int. 2015;2015:418159.
Reference Link
133

Siah WF, Loughman J, O’Brien C.

  • 2015
  • Lower Macular Pigment Optical Density in Foveal-Involved Glaucoma.
  • Ophthalmology. 2015 Oct;122(10):2029-37.
Reference Link
132

Wallace DM, Pokrovskaya O, O’Brien CJ.

  • 2015
  • The Function of Matricellular Proteins in the Lamina Cribrosa and Trabecular Meshwork in Glaucoma.
  • J Ocul Pharmacol Ther. 2015 Sep;31(7):386-95.
Reference Link
131

Murphy RM, Bakir B, O’Brien C, Wiggs JL, Pasquale LR

  • 2015
  • Drug-induced Bilateral Secondary Angle-Closure Glaucoma: A Literature Synthesis.
  • J Glaucoma. 2015 Apr 21. [Epub ahead of print]
Reference Link
130

Wallace DM, Pokrovskaya O, O’Brien CJ.

  • 2015
  • The function of matricellular proteins in the lamina cribrosa and trabecular meshwork in glaucoma.
  • J Ocul Pharmacol Ther. 2015 Apr 7. [Epub ahead of print]
Reference Link
129

Quill B, Irnaten M, Docherty NG, McElnea EM, Wallace DM, Clark AF, O’Brien CJ

  • 2015
  • ‘Calcium channel blockade reduces mechanical strain induced extracellular matrix gene response in lamina cribrosa cells’.
  • Br J Ophthalmol. 2015 Mar 20. pii: bjophthalmol-2014-306093. doi: 10.1136/bjophthalmol-2014-306093. [Epub ahead of print]
Reference Link
128

McElnea EM, Hughes E, McGoldrick A, McCann A, Quill B, Docherty N, Irnaten M, Farrell M, Clark AF, O’Brien CJ, Wallace DM.

  • 2014
  • Lipofuscin accumulation and autophagy in glaucomatous human lamina cribrosa cells.
  • BMC Ophthalmol. 2014 Dec 2;14:153.
Reference Link
127

McNally S,  O’Brien CJ. Metabolomics/Proteomics strategies used to identify biomarkers for exfoliation glaucoma. J Glaucoma. 2014 Oct-Nov;23(8 Suppl 1):S51-4.

  • 2014
  • Metabolomics/Proteomics strategies used to identify biomarkers for exfoliation glaucoma.
  • J Glaucoma. 2014 Oct-Nov;23(8 Suppl 1):S51-4.
Reference Link
126

Sundaresan P, Simpson DA, Sambare C, Duffy S, Lechner J, Dastane A, Dervan EW, Vallabh N, Chelerkar V, Deshpande M, O’Brien C, McKnight AJ, Willoughby CE

  • 2014
  • Whole-mitochondrial genome sequencing in primary open-angle glaucoma using massively parallel sequencing identifies novel and known pathogenic variants.
  • Genet Med. 2014 Sep 18.
Reference Link
125

Gao W, Ferguson G, Connell P, Walshe T, O’Brien C, Redmond EM, Cahill PA.

  • 2014
  • Glucose attenuates hypoxia-induced changes in endothelial cell growth by inhibiting HIF-1α expression.
  • Diab Vasc Dis Res. 2014 May 22;11(4):270-280.
Reference Link
124

McDonnell F, O’Brien C, Wallace D.

  • 2014
  • The role of epigenetics in the fibrotic processes associated with glaucoma.
  • J Ophthalmol. 2014~:750459.
Reference Link
123

Wallace DM, Murphy-Ullrich JE, Downs JC, O’Brien CJ

  • 2014
  • The role of matricellular proteins in glaucoma.
  • Matrix Biol 2014 Apr 12 pii S0945-053X(14)00058-4
Reference Link
122

Wallace DM, Clarke AF, Lipson KE, Andrews D, Crean JK, O’Brien CJ .

  • 2013
  • Anti-connective tissue growth factor antibody treatment reduces extracellular matrix production in trabecular meshwork and lamina cribrosa cells.
  • Invest Ophthalmol Vis Sci 2013 Dec 2;54(13)7836-48
Reference Link
121

Irnaten M, Barry RC, Wallace DM, Docherty NG, Quill B, Clark AF, O’Brien CJ.

  • 2013
  • Elevated maxi-K(+) ion channel current in glaucomatous lamina cribrosa cells
  • Exp Eye Res 2013 Oct; 115:224-9
Reference Link
120

Igras E, Loughman J, Ratzlaff M, O’Caoimh R, O’Brien C.

  • 2013
  • Evidence of lower macular pigment optical density in chronic open angle glaucoma. Br J Ophthalmol. 2013 Aug;97(8):994-998
  • Br J Ophthalmol. 2013 Aug;97(8):994-998
Reference Link
119

Bhattacharya SK, Lee RK, Grus FH; 

  • 2013
  • Seventh ARVO/Pfizer Ophthalmics Research Institute Conference Working Group. Molecular biomarkers in glaucoma.
  • 2013 Jan 7;54(1):121-31
118

Kirwan RP, Felice L, Clark AF, O’Brien CJ, Leonard MO.

  • 2012
  • Hypoxia regulated gene transcription in human optic nerve lamina cribrosa cells in culture.
  • Invest Ophthalmol Vis Sci. 2012 53:2243-2255
Reference Link
117

Wiggs JL, Hewitt AW, Fan BJ, Wang DY, Figueiredo Sena DR, O’Brien C, Realini A, Craig JE, Dimasi DP, Mackey DA, Haines JL, Pasquale LR.

  • 2012
  • The p53 codon 72 PRO/PRO genotype may be associated with initial central visual field defects in caucasians with primary open angle glaucoma.
  • PLoS One. 2012;7(9):e45613. doi: 10.1371/journal.pone.0045613. Epub 2012 Sep 26
Reference Link
116

Walshe TE, Connell P, Cryan L, Ferguson G, Gardiner T, Morrow D, Redmond EM, O’Brien C, Cahill PA

  • 2011
  • Microvascular retinal endothelial and pericyte cell apoptosis in vitro: role of Hedgehog and Notch signaling.
  • Invest Ophthalmol Vis Sci. 2011 . Jun 23;52(7):4472-83.
Reference Link
115

Browne JG, Ho SL, Kane R, Oliver N, Clark AF, O’Brien CJ, Crean JK.

  • 2011
  • Connective Tissue Growth Factor is increased in Pseudoexfoliation Glaucoma.
  • Invest Ophthalmol Vis Sci. 2011 Jun 1;52(6):3660-6
Reference Link
114

Gallagher BA, Hart PM, O’Brien C, Stevenson MR, Jackson AJ.

  • 2011
  • Mobility and access to transport issues as experienced by people with vision impairment living in urban and rural Ireland.
  • Disabil Rehabil. 2011;33(12):979-88.
Reference Link
113

McElnea EM, Quill B, Docherty NG, Irnaten M, Siah WF, Clark AF, O’Brien CJ, Wallace DM

  • 2011
  • Oxidative stress, mitochondrial dysfunction and calcium overload in human lamina cribrosa cells from glaucoma donors.
  • Mol Vis. 2011;17:1182-91.
Reference Link
112

Guerin M, Cotter T, McKernan D, O’Brien C.

  • 2011
  • Age Dependent Rat Retinal Ganglion Cell Susceptibility to Apoptotic Stimuli: Implications for Glaucoma.
  • Clin & Exper Ophthalmol Apr;39(3):243-51. 2011
Reference Link
111

Quill B, Docherty N, Clark AF, O’Brien CJ.

  • 2011
  • The Effect of Graded Cyclic Stretch on Extracellular Matrix Related Gene Expression Profiles in Cultured Primary Human Lamina Cribrosa Cells.
  • Invest Ophthalmol Vis Sci. 2011; Mar 30;52(3):1908-15.
Reference Link
110

Farrell SM, Groeger G, Bhatt L, Finnegan S, O’Brien CJ, Cotter TG.

  • 2011
  • bFGF-mediated redox activation of the PI3K/Akt pathway in retinal photoreceptor cells.
  • Eur J Neurosci. 2011 Feb;33(4):632-41.
Reference Link
109

Walshe TE, Connell P, Cryan L, Ferguson G, O’Brien C, Cahill PA.

  • 2011
  • The role of pulsatile flow in controlling microvascular retinal endothelial and pericyte cell apoptosis and proliferation.
  • Cardiovasc Res. 2011 Feb 15;89(3):661-70.
Reference Link
108

P O’Connor R, Cryan LM, Wynne K, de Stefani A, Fitzgerald D, O’Brien C, Cagney G.

  • 2010
  • Proteomics strategy for identifying candidate bioactive proteins in complex mixtures: application to the platelet releasate.
  • J Biomed Biotechnol. 2010; 2010:107859.
Reference Link
107

Dervan EW, Chen H, Ho SL, Brummel N, Schmid J, Toomey D, Haralambova M, Gould E, Wallace DM, Prehn JH, O’Brien C, Murphy D.

  • 2010
  • Protein Macroarray Profiling of Serum Autoantibodies in Pseudoexfoliation Glaucoma.
  • Invest Ophthalmol Vis Sci. 2010 Jun;51(6):2968-75.
Reference Link
106

Quaranta L, Konstas AG, Rossetti L, Garcia-Feijoo J, O’Brien C, Nasr MB, Fogagnolo P, Demos CM, Stewart JA, Stewart WC.

  • 2010
  • Untreated 24-h intraocular pressures measured with Goldmann applanation tonometry vs nighttime supine pressures with Perkins applanation tonometry.
  • Eye (Lond). 2010 Jul;24(7):1252-8. Epub 2009 Dec 4.
Reference Link
105

Kirwan RP, Wordinger RJ, Clark AF, O’Brien CJ.

  • 2009
  • Differential global and extra-cellular matrix focused gene expression patterns between normal and glaucomatous human lamina cribrosa cells.
  • Mol Vis. 2009;15:76-88. Epub 2009 Jan 15.
Reference Link
104

Irnaten M, Barry RC, Quill B, Clark AF, Harvey BJ, O’Brien CJ.

  • 2009
  • Activation of stretch-activated channels and maxi-K+ channels by membrane stress of human lamina cribrosa cells.
  • Invest Ophthalmol Vis Sci. 2009 Jan;50(1):194-202. Epub 2008 Sep 4.
Reference Link
103

Cryan L, Fitzgerald D, O’Brien C.

  • 2009
  • Ocular prostaglandin production and morphology in mice lacking a single isoform of cyclogenase.
  • Prostaglandins, Leuko & Essent Fatty Acids 2009 81:401-9.
Reference Link
102

Guerin M, Flynn T, Brady J, O’Brien C.

  • 2008
  • Worldwide geographical distribution of ophthalmic publications.
  • Int Ophthalmol; 2008; 29: 511-6.
Reference Link
101

Cryan L, O’Brien C.

  • 2008
  • Proteomics as a research tool in clinical and experimental ophthalmology.
  • Proteomics Clin. App. 2008; 2(5); 762-75
Reference Link
100

Morrow D, Guha S, Sweeney C, Birney Y, Walshe T, O’Brien C, Walls D, Redmond EM, Cahill PA.

  • 2008
  • Notch and vascular smooth muscle cell phenotype.
  • Circ Res. 2008 Dec 5;103(12):1370-82.
Reference Link
099

O’Connor JC, Wallace DM, O’Brien C, Cotter TG. A novel antioxidant function for the tumour suppressor gene p53 in the retinal ganglion cell.

  • 2008
  • A novel antioxidant function for the tumour suppressor gene p53 in the retinal ganglion cell.
  • Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4237-44
Reference Link
098

Kane R, Godson C, O’Brien C.

  • 2008
  • Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis.
  • Mol Vis. 2008 Jun 20;14:1138-48.
Reference Link
097

O’Driscoll C, O’Connor J, O’Brien CJ, Cotter TG.

  • 2008
  • Basic fibroblast growth factor-induced protection from light damage in the mouse retina in vivo.
  • J Neurochem. 2008 Apr;105(2):524-36. Epub 2007 Dec 13.
Reference Link
096

Aragon-Martin JA, Ritch R, Liebmann J, O’Brien C, Blaaow K, Mercieca F, Spiteri A, Cobb CJ, Damji KF, Tarkkanen A, Rezaie T, Child AH, Sarfarazi M.

  • 2008
  • Evaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma.
  • Mol Vis. 2008 Mar 17;14:533-41.
Reference Link
095

Cryan LM, Paraoan L, Hiscott P, Damato BE, Grierson I, Gray D, Farrell M, Doherty GA, Fitzgerald DJ, O’Brien C.

  • 2008
  • Expression of COX-2 and prognostic outcome in uveal melanoma.
  • Curr Eye Res. 2008 Feb;33(2):177-84.
Reference Link
094

Horgan N, Kirwan RP, O’Brien CJ.

  • 2007
  • Choroidal detachment associated with latanoprost use in the fellow eye.
  • Ann Pharmacother. 2007 Jan;41(1):161-2.
Reference Link
093

Gao W, Ferguson G, Connell P, Walshe T, Murphy R, Birney YA, O’Brien C, Cahill PA.

  • 2007
  • High glucose concentrations alter hypoxia-induced control of vascular smooth muscle cell growth via a HIF-1alpha-dependent pathway.
  • J Mol Cell Cardiol. 2007 Mar;42(3):609-19. Epub 2006 Dec 21.
Reference Link
092

Connell P, Walshe T, Ferguson G, Gao W, O’Brien C, Cahill PA.

  • 2007
  • Elevated glucose attenuates agonist- and flow-stimulated endothelial nitric oxide synthase activity in microvascular retinal endothelial cells.
  • Endothelium. 2007 Jan-Feb;14(1):17-24.
Reference Link
091

Lee H, O’Meara SJ, O’Brien C, Kane R.

  • 2007
  • The role of gremlin, a BMP antagonist, and epithelial-to-mesenchymal transition in proliferative vitreoretinopathy.
  • Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4291-9.
Reference Link
090

McKernan DP, Guerin MB, O’Brien CJ, Cotter TG. A key role for calpains in retinal ganglion cell death.

  • 2007
  • Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5420-30.
Reference Link
089

Guerin MB, McKernan DP, O’Brien CJ, Cotter TG.

  • 2006
  • Retinal ganglion cells: dying to survive.
  • Int J Dev Biol. 2006;50(8):665-74..
Reference Link
088

Y Delaney, T Walshe, C O’Brien.

  • 2006
  • Vasospasm in glaucoma: clinical and laboratory aspects.
  • Optom Vis Sci. 2006 Jul;83(7):406-14.
Reference Link
087

E Henry, D Newby, DJ Webb, PW Hadoke, C O’Brien.

  • 2006
  • Altered endothelin-1 vasoreactivity in patients with untreated normal-pressure glaucoma.
  • Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2528-32.
Reference Link
086

L Cryan, G Pidgeon, D Fitzgerald, C O’Brien.

  • 2006
  • COX-2 protects against thrombosis of the retinal vasculature in a mouse model of proliferative retinopathy.
  • Mol Vis. 2006 Apr 20;12:405-14
Reference Link
085

C Kelliher, D Kenny, C O’Brien.

  • 2006
  • Trends in blind registration in the adult population of the Republic of Ireland. 1996-2003.
  • Br J Ophthalmol 2006 Mar;90(3)367-71.
Reference Link
084

McKernan DP, Caplis C, Donovan M, O’Brien C, Cotter T.

  • 2006
  • Age-dependent susceptibility of the retinal ganglion cell layer to cell death.
  • Invest Ophthalmol Vis Sci. 2006 Mar;47(3):807-14.
Reference Link
083

A Knox, M Barry, C O’Brien.

  • 2006
  • The rising cost of glaucoma drugs in Ireland. 1996-2003.
  • Br J Ophthalmol 2006 Feb;90(2):162-5
Reference Link
082

R Kane, L Stevenson, C Godson, A Stitt, C O’Brien.

  • 2005
  • Gremlin gene expression in bovine retinal pericytes exposed to elevated glucose.
  • Br J Ophthalmol 2005; Dec;89(12): 1638-42
Reference Link
081

R Kirwan, C Fenerty, J Crean, R Wordinger, A F Clark, C O’Brien

  • 2005
  • Influence of cyclical mechanical strain on extracellular matrix gene expression in human lamina cribrosa cells in vitro.
  • Mol Vis 2005 Sep 23;11:798-810
Reference Link
080

R Kirwan, M O’Leonard, M Murphy A F Clark, C O’Brien

  • 2005
  • Transforming growth factor-beta-regulated gene transcription and protein expression in human GFAP-negative lamina cribrosa cells.
  • Glia. 2005 Dec;52(4):309-24.
Reference Link
079

VW Long, C O’Brien.

  • 2005
  • Trends in ophthalmic surgery in Ireland.
  • Irish Journal Med. Sci 2005; 174 (2); 36-39
Reference Link
078

P Aspinall, A Hill, P Nelson, C O’Brien, E O’Connell, L McCloughan, A Azuara-Blanco, R Brice, S Green, C Steeds.

  • 2005
  • Quality of life in patients with glaucoma: a conjoint analysis approach.
  • Visual Impairment Research 2005; 7 (1): 13-26.
Reference Link
077

T E Walshe, G Ferguson, P Connell, C O’Brien, P A Cahill.

  • 2005
  • Pulsatile flow increases the expression of eNOS, ET-1, and Prostacyclin in a novel in vitro coculture model of the retinal vasculature.
  • Invest Ophthal Vis Sci 2005;Jan(46)1:375-382.
Reference Link
076

C Cleary, C H Buckley, E Henry, P McLoughlin, C O’Brien, P W Hadoke.

  • 2005
  • Enhanced endothelium derived hyperpolarized factor activity in resistance arteries from normal pressure glaucoma patients: implications for vascular function in the eye.
  • Br J Ophthalmol 2005;89:223-228
Reference Link
075

S L Ho, G F Dogar, J Wang, J Crean, Q D Wu, N Oliver, S Weitz, A Murray, P E Cleary, C O’Brien.

  • 2005
  • Elevated aqueous humour tissue inhibitor of matrix metalloproteinase-1 and connective tissue growth factor in pseudoexfoliation disease.
  • Br J Ophthalmol 2005;89:169-173.
Reference Link
074

Morgan-Davies J, Taylor N, Hill AR, Aspinall P, O’Brien CJ, Asuara-Blanco A.

  • 2004
  • Three dimensional analysis of the lamina cribrosa in glaucoma.
  • Br J Ophthalmol 2004 Oct;88(10): 1299-304.
Reference Link
073

R Kirwan, J Crean, C Fenerty, A Clark, C O’Brien.

  • 2004
  • Effect of cyclical mechanical stretch and exogenous transforming growth factor-B1 on matrix metalloproteinase-2 activity in lamina cribrosa cells from the human optic nerve head.
  • J Glaucoma 2004 Aug; 13(4): 327-34.
Reference Link
072

J Stokes, R Best, C O’Brien, J Seckl.

  • 2003
  • Altered glucocorticoid peripheral sensitivity in glaucoma.
  • Invest Ophthal Vis Sci 2003; Dec 44(12) 5163-7.
Reference Link
071

J Kerr, C O’Brien.

  • 2003
  • Ocular blood flow in untreated ocular hypertension.
  • Am J Ophthalmology 2003 Dec 136(6) 1106-13.
Reference Link
070

S Quinn, C O’Brien, P McLoughlin.

  • 2003
  • Nitric oxide independent vasorelaxation in the bovine long posterior ciliary artery.
  • Eye 2003 July 17(5) 628-36.
Reference Link
069

P Nelson, P Aspinall, C O’Brien.

  • 2003
  • The relationship between quality of life and visual function in glaucoma.
  • J Glaucoma 2003 Apr 12(2) 139-50.
Reference Link
068

Buckley C, Hadoke P, Henry E, O’Brien C.

  • 2002
  • Systemic vascular endothelial dysfunction in normal pressure glaucoma
  • Br J Ophthalmology 2002; 86; 227-32.
Reference Link
067

O’Toole L, Cahill M, O’Brien C.

  • 2001
  • Eyelid hypertrichosis associated with latanoprost is reversible.
  • Eur J Ophthalmol. 2001 Oct-Dec;11(4):377-9.
Reference Link
066

Devlin H, O’Brien C.

  • 2001
  • Normal tension glaucoma: Diagnosis and Management.
  • CME Journal Ophthalmol 2001; 5(1): 13-17.
065

Morgan-Davies J, King A, Aspinall P, O’Brien C.

  • 2000
  • Measurement of a novel optic disc topographic parameter ‘spikiness’ in glaucoma.
  • Graefe’s Arch Clin Exp Ophthalmol 2000, 238: 669- 76.
Reference Link
064

McKinnon J, McKillop G, Swa K, O’Brien C, Butt Z, Nelson P.

  • 2000
  • Colour Doppler imaging of the ocular circulation in diabetic retinopathy.
  • Acta Ophthalmol, 2000, 78: 386-9.
Reference Link
063

Stokes J, Andrew R, Seckyl J, O’Brien C.

  • 2000
  • Glucocorticoid and mineralocorticoid receptors and 11-beta-deyhydrogenase activity in rat and human ocular tissue.
  • Invest Ophthalmol Vis Sci 2000; 41: 1629-38.
Reference Link
062

King A, Bolton N, Aspinall P, O’Brien C.

  • 2000
  • Retinal nerve fibre layer volume in glaucoma.
  • Am J Ophthalmol 2000, 129: 599-607.
Reference Link
061

J Stokes, E Henry, C O’Brien.

  • 1998/1999
  • Differential Diagnosis of Normal Tension Glaucoma (1998)
  • In: Pillunat L, Harris A (eds) Fortbildurg Glaucoma. Enke Verlag, Stuggart, 1999.
060

O’Brien C, Butt Z.

  • 1999
  • Blood flow velocity in the peripheral circulation of glaucoma patients.
  • Ophthalmologica 1999; 213: 150-153.
Reference Link
059

Henry E, Newby DE, Webb DJ, O’Brien C.

  • 1999
  • Peripheral endothelial dysfunction in normal pressure glaucoma.
  • Invest Ophthalmol Vis Sci 1999; 40: 1710-1714.
Reference Link
058

Nelson P, Aspinall P, O’Brien C.

  • 1999
  • Patients’ perception of visual impairment in glaucoma. A pilot study.
  • Br J Ophthalmol 1999; 83: 546-552.
Reference Link
057

Edgar DF, Crabb DP, Rudnicka AR, Lawrensen JG, Gutteridge NM, O’Brien C.

  • 1999
  • Effects of dipivefrin and pilocarpine on pupil diameter, automated perimetry and Logmar acuity.
  • Graefe’s Arch Clin Exp Ophthalmol 1999; 237: 117-24.
Reference Link
056

Buckley C H, Hadoke P, O’Brien C.

  • 1998
  • Role of the endothelium in modulating functional responses of isolated bovine anterior ciliary arteries to vasoconstrictor agonists.
  • Br J Ophthalmol 1998; 82: 826-829.
Reference Link
055

Fontana L, Poinoosawmy D, Bunce CV, O’Brien C, Hitchings RA.

  • 1998
  • Pulsatile ocular blood flow investigation in asymmetric normal-tension glaucoma and normal subjects.
  • Br J Ophthalmol 1998; 82: 731-6.
Reference Link
054

Kelly PA, Buckley C, Ritchie IM, O’Brien C.

  • 1998
  • Possible role for nitric oxide releasing nerves in the regulation of ocular blood flow in the rat.
  • Br J Ophthalmol 1998; 82: 1199-202.
Reference Link
053

O’Brien C

  • 1998
  • Vasospasm and glaucoma (Editorial).
  • Br J Ophthalmol 1998; 82: 855-6.
Reference link
052

Kerr J, Nelson P, O’Brien C.

  • 1998
  • A comparison of ocular blood flow in untreated primary open-angle glaucoma and ocular hypertension.
  • Am J Ophthalmol 1998; 126: 42-51.
Reference link
051

C. O’Brien.

  • 1998
  • Is there a role for computerised image analysis in glaucoma management.
  • Br. J Ophthalmol 1998, 82: 2-3. (Editorial).
Reference link
050

C Buckley, P Hadoke, C O’Brien.

  • 1997
  • The use of isolated ocular arteries in-vitro to define the pathology of vascular changes in glaucoma.
  • Br J Ophthalmol 1997, 81:599 - 607
Reference Link
049

JR Mackinnon, Z Butt, K Swa, C O’Brien.

  • 1997
  • Pulsatile ocular blood flow in untreated diabetic retinopathy.
  • Acta Ophthalmol, 1997; 75:6, 661-4.
Reference Link
048

RWD Bell, NE Habib, C O’Brien.

  • 1997
  • Long-term outcome and complications of trabeculectomy with a single per-operative application of 5-fluorouracil.
  • Eye 1997;11: 663-71.
Reference Link
047

RS Anderson, C O’Brien.

  • 1997
  • Psychophysical evidence for selective loss of M ganglion cells in glaucoma
  • Vis Res 1997 , 37: 1079-1083.
Reference Link
046

RWD Bell, HK Yang, C O’Brien.

  • 1997
  • A case of bilateral cavernous hemangioma associated with intra-cerebral hemangioma.
  • Arch Ophthalmol 1997, 115:6, 818-9.
Reference Link
045

C O’Brien, Z Butt, C Ludlum.

  • 1997
  • Activation of the coagulation cascade in untreated primary open angle glaucoma.
  • Ophthalmol 1997; 104:725 - 730
Reference Link
044

Z Butt, C O’Brien, G McKillop, P Aspinall, P Allan.

  • 1997
  • Colour Doppler imaging in untreated high and normal pressure open angle glaucoma.
  • Invest Ophthalmol Vis Sci, 1997; 38: 690-6.
Reference Link
043

C O’Brien, P Kelly, I Ritchie.

  • 1997
  • The effect of chronic inhibition of nitric oxide synthase on ocular blood flow and glucose metabolism in rats.
  • Br J Ophthalmol 1997;81:68-71.
Reference Link
042

RWD Bell, C O’Brien.

  • 1997
  • Accuracy of referral to a glaucoma clinic.
  • Ophthal Physiol Opt 1997;17:7-11.
Reference Link
041

RWD Bell, C O’Brien.

  • 1997
  • Diagnostic outcome of hospital glaucoma referrals.
  • Ophthal Physiol Opt 1997;17:3-6.
Reference Link
040

A Kosmin, M Austin, C.O’Brien, N. Cotu, P. Wishart.

  • 1996/1997
  • Ageing changes in automated perimetry. A comparison of flicker and luminance sensitivity in normal subjects.
  • In: Wall M, Heijl A (eds). Perimetry update 1996/1997. Kugler: Amsterdam, New York 1997, pp 229 - 233.
039

FD Ghanchi, TH Williamson, CS Lim, Z Butt, GM Baxter, G McKillop, C O’Brien.

  • 1996
  • Colour Doppler imaging in giant cell (temporal) arteritis: serial examination and comparison with non-arteritic anterior ischaemic optic neuropathy.
  • Eye 1996;10:459-464.
Reference Link
038

C Lim, C O’Brien, N Bolton.

  • 1996
  • A simple clinical method to measure the optic disc size in glaucoma.
  • J Glaucoma 1996;5:241-245.
Reference Link
037

J Sing, R Bell, A Adams, C O’Brien,

  • 1996
  • Enhancement of post trabeculectomy bleb formation by laser suture lysis.
  • Br J Ophthalmol 1996;80:624-627.
Reference Link
036

RS Ayyala, C O’Brien, I Grierson, P Maltby.

  • 1996
  • Transcleral flow of aqueous humor: an in-vitro experiment.
  • Ophthalmol Surg 1996;27:66-69.
Reference Link
035

M Birch, S Barbosa, L Blumhardt, C O Brien, S Harding.

  • 1996
  • Retinal venous sheathing and the blood-retinal barrier in multiple sclerosis.
  • Arch Ophthalmol 1996;114-119.
Reference Link
034

RS Anderson, P Detkova, C O’Brien.

  • 1995
  • Effect of temporal frequency and contrast on peripheral grating resolution.
  • Curr Eye Res 1995;14:1031-1033.
Reference Link
033

GP Rao, C O’Brien, MH Dwyer, A Patterson.

  • 1995
  • Rapid onset bilateral calcific band keratopathy associated with phosphate containing steroid eye drops.
  • Eur J Implant Refr Surg 1995;7:251-252.
Reference Link
032

A King, D David, H Jones, C O’Brien.

  • 1995
  • Non-attendance at an ophthalmic out-patient department.
  • J Roy Soc Med 1995;88:88-90.
Reference Link
031

J Sing, H Chawla, C O’Brien.

  • 1995
  • Success rate and complications of intraoperative mitomycin-C in trabeculectomy surgery.
  • Eye 1995;9:460-466.
reference Link
030

Z Butt, C O’Brien.

  • 1995
  • Reproducibility of pulsatile ocular blood flow measurements.
  • J Glaucoma 1995;4:214-218.
Reference Link
029

C O’Brien, J Wild.

  • 1995
  • Automated perimetry in glaucoma - room for improvement?
  • Br J Ophthalmol 1995;79:200-201. (editorial)
Reference Link
028

Z Butt, G McKillop, C O’Brien, P Allan, P Aspinall.

  • 1995
  • Measurement of ocular blood flow velocity using colour Doppler imaging in low tension glaucoma.
  • Eye 1995, 9:29-33.
Reference Link
027

D. Broadway, I Grierson, C O’Brien, R Hitchings.

  • 1994
  • Adverse effects of topical anti-glaucoma medications. Part II. The outcome of filtration surgery.
  • Arch Ophthalmol 1994;112:1446-1454.
Reference Link
026

D Broadway, I Grierson, C O’Brien, RA Hitchings.

  • 1994
  • Adverse effects of topical anti-glaucoma medications. Part I. The conjunctival cell profile.
  • Arch Ophthalmol 1994;112:1437-1445.
Reference Link
025

C de Vivero, C O’Brien, L Lanigan, RA Hitchings.

  • 1994
  • Diurnal intraocular pressure variation in low tension glaucoma.
  • Eye 1994;8:521-523.
Reference Link
024

C O’Brien, D Clark.

  • 1994
  • Ocular biometry in preterm infants without retinopathy of prematurity.
  • Eye 1994;8:662-665.
Reference Link
023

M Austin, C O’Brien, P Wishart.

  • 1994
  • Flicker perimetry using a luminance threshold strategy at frequencies from 5-25Hz in glaucoma, ocular hypertension and normal controls.
  • Curr Eye Res 1994;13:7171-724.
Reference Link
022

DE Laws, R Haslett, D Ashby, C O’Brien, D Clark.

  • 1994
  • Axial length biometry in infants with retinopathy of prematurity.
  • Eye 1994;8:427-430.
Reference Link
021

C O’Brien, D Poinoosawmy, J Wu, R Hitchings.

  • 1994
  • Evaluation of a rapid thresholding program (Fastpac) in glaucoma.
  • Br J Ophthalmol 1994;78:516-9.
Reference Link
020

MW Austin, C O’Brien, PE Wishart.

  • 1994/1995
  • Forced choice flicker perimetry in glaucoma.
  • In: Perimetry Update 1994/1995; (eds) RP Mills, M Wall. Kugler Publ, Amsterdam, pp 135-140.
019

K. Evans, C O’Brien, A Patterson.

  • 1994
  • Corneal endothelial response to corticosteroid in cataract surgery.
  • Eur J Implant Refr Surg 1994;6:74-78.
Reference Link
018

B Moriarty, C O’Brien.

  • 1993
  • Cataract surgery in the glaucoma patient.
  • In: Ball S, Franklin R (eds); Trans New Orleans and Acad Ophthalmol - Glaucoma, Diagnosis and Therapy 1993. Kugler Publ, Amstelveen pp 159-168.
017

J. Singh, C O’Brien, M Wright.

  • 1993
  • Nebulised bronchodilator therapy causes acute angle closure glaucoma in predisposed individuals.
  • Resp Med 1993, 187:559-561
Reference Link
016

C O’Brien, JD Young, M Brown, C Short, M Bone.

  • 1993
  • Electrophysiology of type 2 mesangio-capillary glomerulonephritis with associated fundus abnormalities.
  • Br J Ophthalmol 1993;77:778-780.
reference Link
015

L Lanigan, C O’Brien, R Hitchings.

  • 1992
  • “Bubble sight”.
  • BMJ (Minerva) 1992;305:1588.
014

M Cox, C. O’Brien.

  • 1992
  • Comparison of computer assisted versus manual optic nerve head pallor measurement.
  • Invest Ophthalmol Vis Sci 1992;33:3169-3173.
Reference Link
013

D. Clark, C O’Brien, M Weindling, M Saed.

  • 1992
  • Initial experience of screening for retinopathy of prematurity.
  • Arch Dis Child 1992;67:1233-1236.
Reference Link
012

C. O’Brien, V Saxton, RP Crick, HB Meire.

  • 1992
  • Doppler carotid artery studies in asymmetric glaucoma.
  • Eye 1992;6:273-276
Reference Link
011

D. Poinoosawmy, J Sturmer, C O’Brien, J Wu, R Hitchings.

  • 1992
  • Is diffuse visual field loss in low tension glaucoma a prognostic indicator for progression.
  • In: Mills RP (ed). Perimetry Update 1992/93. Kugler Publ. Amsterdam, pp 121-127.
010

C O’Brien, M Austin, P Wareing, P Hammond.

  • 1992
  • Clinical evaluation of a new combined automated flicker and static perimeter.
  • In: Mills RP (ed). Perimetry Update 1992/93. Kugler Publ: Amsterdam, pp 603-606.
009

C O’Brien, B Schwartz.

  • 1992
  • Point by point linear regression analysis of automated visual fields in chronic open angle glaucoma.
  • In: Perimetry Update 1992/93; Mills RP (ed). Kugler Publ, Amsterdam, pp 149-152.
008

C. O’Brien, B Schwartz, T Takamoto.

  • 1991
  • Correlation of optic disc cupping, pallor and retinal nerve fibre layer thickness with visual field loss in chronic open angle glaucoma.
  • In: Perimetry Update 1991; eds Mills and Heijl: Kugler Publ, Amsterdam pp15-19.
Reference Link
007

C. O’Brien. Optic disc pallor measurement.

  • 1991
  • Optic disc pallor measurement.
  • Eye 1991;5:763.
Reference Link
006

J. Butcher, C. O’Brien.

  • 1991
  • The reproducibility of biometry and keratometry.
  • Eye 1991;5:708-711.
Reference Link
005

C. O’Brien, B Schwartz, T Takamoto, DC Wu.

  • 1991
  • Intraocular pressure and the rate of change of the visual field in chronic open angle glaucoma.
  • Am J Ophthalmol 1991;111:491-497.
Reference Link
004

McAllister, C. O’Brien. Neodymium:Yag transcleral cyclocoagulation: a clinical study.

  • 1990
  • Neodymium:Yag transcleral cyclocoagulation: a clinical study.
  • Eye 1990;4:651-654.
Reference Link
003

C. O’Brien, B Schwartz. The visual field in chronic open angle glaucoma:

  • 1990
  • The visual field in chronic open angle glaucoma: the rate of change in the different regions of the field.
  • Eye 1990;4:557-562.
Reference Link
002

CJ O’Brien, I Grierson, J McAllister. Treatment parameters for

  • 1990
  • transcleral cyclocoagulation with the Neodymium:Yag laser.
  • Lasers Ophthalmol 1990;3:221-225.
Reference Link
001

C J O’Brien, GM Kyle

  • 1988
  • Metastatic staphylococcus aureas endophthalmitis:
  • Br J Ophthalmol 1988;72:189-91.
Reference Link
Showing 1 - 177 out of 177
001

C J O’Brien, GM Kyle

  • 1988
  • Metastatic staphylococcus aureas endophthalmitis:
  • Br J Ophthalmol 1988;72:189-91.
Reference Link
002

CJ O’Brien, I Grierson, J McAllister. Treatment parameters for

  • 1990
  • transcleral cyclocoagulation with the Neodymium:Yag laser.
  • Lasers Ophthalmol 1990;3:221-225.
Reference Link
003

C. O’Brien, B Schwartz. The visual field in chronic open angle glaucoma:

  • 1990
  • The visual field in chronic open angle glaucoma: the rate of change in the different regions of the field.
  • Eye 1990;4:557-562.
Reference Link
004

McAllister, C. O’Brien. Neodymium:Yag transcleral cyclocoagulation: a clinical study.

  • 1990
  • Neodymium:Yag transcleral cyclocoagulation: a clinical study.
  • Eye 1990;4:651-654.
Reference Link
005

C. O’Brien, B Schwartz, T Takamoto, DC Wu.

  • 1991
  • Intraocular pressure and the rate of change of the visual field in chronic open angle glaucoma.
  • Am J Ophthalmol 1991;111:491-497.
Reference Link
006

J. Butcher, C. O’Brien.

  • 1991
  • The reproducibility of biometry and keratometry.
  • Eye 1991;5:708-711.
Reference Link
007

C. O’Brien. Optic disc pallor measurement.

  • 1991
  • Optic disc pallor measurement.
  • Eye 1991;5:763.
Reference Link
008

C. O’Brien, B Schwartz, T Takamoto.

  • 1991
  • Correlation of optic disc cupping, pallor and retinal nerve fibre layer thickness with visual field loss in chronic open angle glaucoma.
  • In: Perimetry Update 1991; eds Mills and Heijl: Kugler Publ, Amsterdam pp15-19.
Reference Link
009

C O’Brien, B Schwartz.

  • 1992
  • Point by point linear regression analysis of automated visual fields in chronic open angle glaucoma.
  • In: Perimetry Update 1992/93; Mills RP (ed). Kugler Publ, Amsterdam, pp 149-152.
010

C O’Brien, M Austin, P Wareing, P Hammond.

  • 1992
  • Clinical evaluation of a new combined automated flicker and static perimeter.
  • In: Mills RP (ed). Perimetry Update 1992/93. Kugler Publ: Amsterdam, pp 603-606.
011

D. Poinoosawmy, J Sturmer, C O’Brien, J Wu, R Hitchings.

  • 1992
  • Is diffuse visual field loss in low tension glaucoma a prognostic indicator for progression.
  • In: Mills RP (ed). Perimetry Update 1992/93. Kugler Publ. Amsterdam, pp 121-127.
012

C. O’Brien, V Saxton, RP Crick, HB Meire.

  • 1992
  • Doppler carotid artery studies in asymmetric glaucoma.
  • Eye 1992;6:273-276
Reference Link
013

D. Clark, C O’Brien, M Weindling, M Saed.

  • 1992
  • Initial experience of screening for retinopathy of prematurity.
  • Arch Dis Child 1992;67:1233-1236.
Reference Link
014

M Cox, C. O’Brien.

  • 1992
  • Comparison of computer assisted versus manual optic nerve head pallor measurement.
  • Invest Ophthalmol Vis Sci 1992;33:3169-3173.
Reference Link
015

L Lanigan, C O’Brien, R Hitchings.

  • 1992
  • “Bubble sight”.
  • BMJ (Minerva) 1992;305:1588.
016

C O’Brien, JD Young, M Brown, C Short, M Bone.

  • 1993
  • Electrophysiology of type 2 mesangio-capillary glomerulonephritis with associated fundus abnormalities.
  • Br J Ophthalmol 1993;77:778-780.
reference Link
017

J. Singh, C O’Brien, M Wright.

  • 1993
  • Nebulised bronchodilator therapy causes acute angle closure glaucoma in predisposed individuals.
  • Resp Med 1993, 187:559-561
Reference Link
018

B Moriarty, C O’Brien.

  • 1993
  • Cataract surgery in the glaucoma patient.
  • In: Ball S, Franklin R (eds); Trans New Orleans and Acad Ophthalmol - Glaucoma, Diagnosis and Therapy 1993. Kugler Publ, Amstelveen pp 159-168.
019

K. Evans, C O’Brien, A Patterson.

  • 1994
  • Corneal endothelial response to corticosteroid in cataract surgery.
  • Eur J Implant Refr Surg 1994;6:74-78.
Reference Link
020

MW Austin, C O’Brien, PE Wishart.

  • 1994/1995
  • Forced choice flicker perimetry in glaucoma.
  • In: Perimetry Update 1994/1995; (eds) RP Mills, M Wall. Kugler Publ, Amsterdam, pp 135-140.
021

C O’Brien, D Poinoosawmy, J Wu, R Hitchings.

  • 1994
  • Evaluation of a rapid thresholding program (Fastpac) in glaucoma.
  • Br J Ophthalmol 1994;78:516-9.
Reference Link
022

DE Laws, R Haslett, D Ashby, C O’Brien, D Clark.

  • 1994
  • Axial length biometry in infants with retinopathy of prematurity.
  • Eye 1994;8:427-430.
Reference Link
023

M Austin, C O’Brien, P Wishart.

  • 1994
  • Flicker perimetry using a luminance threshold strategy at frequencies from 5-25Hz in glaucoma, ocular hypertension and normal controls.
  • Curr Eye Res 1994;13:7171-724.
Reference Link
024

C O’Brien, D Clark.

  • 1994
  • Ocular biometry in preterm infants without retinopathy of prematurity.
  • Eye 1994;8:662-665.
Reference Link
025

C de Vivero, C O’Brien, L Lanigan, RA Hitchings.

  • 1994
  • Diurnal intraocular pressure variation in low tension glaucoma.
  • Eye 1994;8:521-523.
Reference Link
026

D Broadway, I Grierson, C O’Brien, RA Hitchings.

  • 1994
  • Adverse effects of topical anti-glaucoma medications. Part I. The conjunctival cell profile.
  • Arch Ophthalmol 1994;112:1437-1445.
Reference Link
027

D. Broadway, I Grierson, C O’Brien, R Hitchings.

  • 1994
  • Adverse effects of topical anti-glaucoma medications. Part II. The outcome of filtration surgery.
  • Arch Ophthalmol 1994;112:1446-1454.
Reference Link
028

Z Butt, G McKillop, C O’Brien, P Allan, P Aspinall.

  • 1995
  • Measurement of ocular blood flow velocity using colour Doppler imaging in low tension glaucoma.
  • Eye 1995, 9:29-33.
Reference Link
029

C O’Brien, J Wild.

  • 1995
  • Automated perimetry in glaucoma - room for improvement?
  • Br J Ophthalmol 1995;79:200-201. (editorial)
Reference Link
030

Z Butt, C O’Brien.

  • 1995
  • Reproducibility of pulsatile ocular blood flow measurements.
  • J Glaucoma 1995;4:214-218.
Reference Link
031

J Sing, H Chawla, C O’Brien.

  • 1995
  • Success rate and complications of intraoperative mitomycin-C in trabeculectomy surgery.
  • Eye 1995;9:460-466.
reference Link
032

A King, D David, H Jones, C O’Brien.

  • 1995
  • Non-attendance at an ophthalmic out-patient department.
  • J Roy Soc Med 1995;88:88-90.
Reference Link
033

GP Rao, C O’Brien, MH Dwyer, A Patterson.

  • 1995
  • Rapid onset bilateral calcific band keratopathy associated with phosphate containing steroid eye drops.
  • Eur J Implant Refr Surg 1995;7:251-252.
Reference Link
034

RS Anderson, P Detkova, C O’Brien.

  • 1995
  • Effect of temporal frequency and contrast on peripheral grating resolution.
  • Curr Eye Res 1995;14:1031-1033.
Reference Link
035

M Birch, S Barbosa, L Blumhardt, C O Brien, S Harding.

  • 1996
  • Retinal venous sheathing and the blood-retinal barrier in multiple sclerosis.
  • Arch Ophthalmol 1996;114-119.
Reference Link
036

RS Ayyala, C O’Brien, I Grierson, P Maltby.

  • 1996
  • Transcleral flow of aqueous humor: an in-vitro experiment.
  • Ophthalmol Surg 1996;27:66-69.
Reference Link
037

J Sing, R Bell, A Adams, C O’Brien,

  • 1996
  • Enhancement of post trabeculectomy bleb formation by laser suture lysis.
  • Br J Ophthalmol 1996;80:624-627.
Reference Link
038

C Lim, C O’Brien, N Bolton.

  • 1996
  • A simple clinical method to measure the optic disc size in glaucoma.
  • J Glaucoma 1996;5:241-245.
Reference Link
039

FD Ghanchi, TH Williamson, CS Lim, Z Butt, GM Baxter, G McKillop, C O’Brien.

  • 1996
  • Colour Doppler imaging in giant cell (temporal) arteritis: serial examination and comparison with non-arteritic anterior ischaemic optic neuropathy.
  • Eye 1996;10:459-464.
Reference Link
040

A Kosmin, M Austin, C.O’Brien, N. Cotu, P. Wishart.

  • 1996/1997
  • Ageing changes in automated perimetry. A comparison of flicker and luminance sensitivity in normal subjects.
  • In: Wall M, Heijl A (eds). Perimetry update 1996/1997. Kugler: Amsterdam, New York 1997, pp 229 - 233.
041

RWD Bell, C O’Brien.

  • 1997
  • Diagnostic outcome of hospital glaucoma referrals.
  • Ophthal Physiol Opt 1997;17:3-6.
Reference Link
042

RWD Bell, C O’Brien.

  • 1997
  • Accuracy of referral to a glaucoma clinic.
  • Ophthal Physiol Opt 1997;17:7-11.
Reference Link
043

C O’Brien, P Kelly, I Ritchie.

  • 1997
  • The effect of chronic inhibition of nitric oxide synthase on ocular blood flow and glucose metabolism in rats.
  • Br J Ophthalmol 1997;81:68-71.
Reference Link
044

Z Butt, C O’Brien, G McKillop, P Aspinall, P Allan.

  • 1997
  • Colour Doppler imaging in untreated high and normal pressure open angle glaucoma.
  • Invest Ophthalmol Vis Sci, 1997; 38: 690-6.
Reference Link
045

C O’Brien, Z Butt, C Ludlum.

  • 1997
  • Activation of the coagulation cascade in untreated primary open angle glaucoma.
  • Ophthalmol 1997; 104:725 - 730
Reference Link
046

RWD Bell, HK Yang, C O’Brien.

  • 1997
  • A case of bilateral cavernous hemangioma associated with intra-cerebral hemangioma.
  • Arch Ophthalmol 1997, 115:6, 818-9.
Reference Link
047

RS Anderson, C O’Brien.

  • 1997
  • Psychophysical evidence for selective loss of M ganglion cells in glaucoma
  • Vis Res 1997 , 37: 1079-1083.
Reference Link
048

RWD Bell, NE Habib, C O’Brien.

  • 1997
  • Long-term outcome and complications of trabeculectomy with a single per-operative application of 5-fluorouracil.
  • Eye 1997;11: 663-71.
Reference Link
049

JR Mackinnon, Z Butt, K Swa, C O’Brien.

  • 1997
  • Pulsatile ocular blood flow in untreated diabetic retinopathy.
  • Acta Ophthalmol, 1997; 75:6, 661-4.
Reference Link
050

C Buckley, P Hadoke, C O’Brien.

  • 1997
  • The use of isolated ocular arteries in-vitro to define the pathology of vascular changes in glaucoma.
  • Br J Ophthalmol 1997, 81:599 - 607
Reference Link
051

C. O’Brien.

  • 1998
  • Is there a role for computerised image analysis in glaucoma management.
  • Br. J Ophthalmol 1998, 82: 2-3. (Editorial).
Reference link
052

Kerr J, Nelson P, O’Brien C.

  • 1998
  • A comparison of ocular blood flow in untreated primary open-angle glaucoma and ocular hypertension.
  • Am J Ophthalmol 1998; 126: 42-51.
Reference link
053

O’Brien C

  • 1998
  • Vasospasm and glaucoma (Editorial).
  • Br J Ophthalmol 1998; 82: 855-6.
Reference link
054

Kelly PA, Buckley C, Ritchie IM, O’Brien C.

  • 1998
  • Possible role for nitric oxide releasing nerves in the regulation of ocular blood flow in the rat.
  • Br J Ophthalmol 1998; 82: 1199-202.
Reference Link
055

Fontana L, Poinoosawmy D, Bunce CV, O’Brien C, Hitchings RA.

  • 1998
  • Pulsatile ocular blood flow investigation in asymmetric normal-tension glaucoma and normal subjects.
  • Br J Ophthalmol 1998; 82: 731-6.
Reference Link
056

Buckley C H, Hadoke P, O’Brien C.

  • 1998
  • Role of the endothelium in modulating functional responses of isolated bovine anterior ciliary arteries to vasoconstrictor agonists.
  • Br J Ophthalmol 1998; 82: 826-829.
Reference Link
057

Edgar DF, Crabb DP, Rudnicka AR, Lawrensen JG, Gutteridge NM, O’Brien C.

  • 1999
  • Effects of dipivefrin and pilocarpine on pupil diameter, automated perimetry and Logmar acuity.
  • Graefe’s Arch Clin Exp Ophthalmol 1999; 237: 117-24.
Reference Link
058

Nelson P, Aspinall P, O’Brien C.

  • 1999
  • Patients’ perception of visual impairment in glaucoma. A pilot study.
  • Br J Ophthalmol 1999; 83: 546-552.
Reference Link
059

Henry E, Newby DE, Webb DJ, O’Brien C.

  • 1999
  • Peripheral endothelial dysfunction in normal pressure glaucoma.
  • Invest Ophthalmol Vis Sci 1999; 40: 1710-1714.
Reference Link
060

O’Brien C, Butt Z.

  • 1999
  • Blood flow velocity in the peripheral circulation of glaucoma patients.
  • Ophthalmologica 1999; 213: 150-153.
Reference Link
061

J Stokes, E Henry, C O’Brien.

  • 1998/1999
  • Differential Diagnosis of Normal Tension Glaucoma (1998)
  • In: Pillunat L, Harris A (eds) Fortbildurg Glaucoma. Enke Verlag, Stuggart, 1999.
062

King A, Bolton N, Aspinall P, O’Brien C.

  • 2000
  • Retinal nerve fibre layer volume in glaucoma.
  • Am J Ophthalmol 2000, 129: 599-607.
Reference Link
063

Stokes J, Andrew R, Seckyl J, O’Brien C.

  • 2000
  • Glucocorticoid and mineralocorticoid receptors and 11-beta-deyhydrogenase activity in rat and human ocular tissue.
  • Invest Ophthalmol Vis Sci 2000; 41: 1629-38.
Reference Link
064

McKinnon J, McKillop G, Swa K, O’Brien C, Butt Z, Nelson P.

  • 2000
  • Colour Doppler imaging of the ocular circulation in diabetic retinopathy.
  • Acta Ophthalmol, 2000, 78: 386-9.
Reference Link
065

Morgan-Davies J, King A, Aspinall P, O’Brien C.

  • 2000
  • Measurement of a novel optic disc topographic parameter ‘spikiness’ in glaucoma.
  • Graefe’s Arch Clin Exp Ophthalmol 2000, 238: 669- 76.
Reference Link
066

Devlin H, O’Brien C.

  • 2001
  • Normal tension glaucoma: Diagnosis and Management.
  • CME Journal Ophthalmol 2001; 5(1): 13-17.
067

O’Toole L, Cahill M, O’Brien C.

  • 2001
  • Eyelid hypertrichosis associated with latanoprost is reversible.
  • Eur J Ophthalmol. 2001 Oct-Dec;11(4):377-9.
Reference Link
068

Buckley C, Hadoke P, Henry E, O’Brien C.

  • 2002
  • Systemic vascular endothelial dysfunction in normal pressure glaucoma
  • Br J Ophthalmology 2002; 86; 227-32.
Reference Link
069

P Nelson, P Aspinall, C O’Brien.

  • 2003
  • The relationship between quality of life and visual function in glaucoma.
  • J Glaucoma 2003 Apr 12(2) 139-50.
Reference Link
070

S Quinn, C O’Brien, P McLoughlin.

  • 2003
  • Nitric oxide independent vasorelaxation in the bovine long posterior ciliary artery.
  • Eye 2003 July 17(5) 628-36.
Reference Link
071

J Kerr, C O’Brien.

  • 2003
  • Ocular blood flow in untreated ocular hypertension.
  • Am J Ophthalmology 2003 Dec 136(6) 1106-13.
Reference Link
072

J Stokes, R Best, C O’Brien, J Seckl.

  • 2003
  • Altered glucocorticoid peripheral sensitivity in glaucoma.
  • Invest Ophthal Vis Sci 2003; Dec 44(12) 5163-7.
Reference Link
073

R Kirwan, J Crean, C Fenerty, A Clark, C O’Brien.

  • 2004
  • Effect of cyclical mechanical stretch and exogenous transforming growth factor-B1 on matrix metalloproteinase-2 activity in lamina cribrosa cells from the human optic nerve head.
  • J Glaucoma 2004 Aug; 13(4): 327-34.
Reference Link
074

Morgan-Davies J, Taylor N, Hill AR, Aspinall P, O’Brien CJ, Asuara-Blanco A.

  • 2004
  • Three dimensional analysis of the lamina cribrosa in glaucoma.
  • Br J Ophthalmol 2004 Oct;88(10): 1299-304.
Reference Link
075

S L Ho, G F Dogar, J Wang, J Crean, Q D Wu, N Oliver, S Weitz, A Murray, P E Cleary, C O’Brien.

  • 2005
  • Elevated aqueous humour tissue inhibitor of matrix metalloproteinase-1 and connective tissue growth factor in pseudoexfoliation disease.
  • Br J Ophthalmol 2005;89:169-173.
Reference Link
076

C Cleary, C H Buckley, E Henry, P McLoughlin, C O’Brien, P W Hadoke.

  • 2005
  • Enhanced endothelium derived hyperpolarized factor activity in resistance arteries from normal pressure glaucoma patients: implications for vascular function in the eye.
  • Br J Ophthalmol 2005;89:223-228
Reference Link
077

T E Walshe, G Ferguson, P Connell, C O’Brien, P A Cahill.

  • 2005
  • Pulsatile flow increases the expression of eNOS, ET-1, and Prostacyclin in a novel in vitro coculture model of the retinal vasculature.
  • Invest Ophthal Vis Sci 2005;Jan(46)1:375-382.
Reference Link
078

P Aspinall, A Hill, P Nelson, C O’Brien, E O’Connell, L McCloughan, A Azuara-Blanco, R Brice, S Green, C Steeds.

  • 2005
  • Quality of life in patients with glaucoma: a conjoint analysis approach.
  • Visual Impairment Research 2005; 7 (1): 13-26.
Reference Link
079

VW Long, C O’Brien.

  • 2005
  • Trends in ophthalmic surgery in Ireland.
  • Irish Journal Med. Sci 2005; 174 (2); 36-39
Reference Link
080

R Kirwan, M O’Leonard, M Murphy A F Clark, C O’Brien

  • 2005
  • Transforming growth factor-beta-regulated gene transcription and protein expression in human GFAP-negative lamina cribrosa cells.
  • Glia. 2005 Dec;52(4):309-24.
Reference Link
081

R Kirwan, C Fenerty, J Crean, R Wordinger, A F Clark, C O’Brien

  • 2005
  • Influence of cyclical mechanical strain on extracellular matrix gene expression in human lamina cribrosa cells in vitro.
  • Mol Vis 2005 Sep 23;11:798-810
Reference Link
082

R Kane, L Stevenson, C Godson, A Stitt, C O’Brien.

  • 2005
  • Gremlin gene expression in bovine retinal pericytes exposed to elevated glucose.
  • Br J Ophthalmol 2005; Dec;89(12): 1638-42
Reference Link
083

A Knox, M Barry, C O’Brien.

  • 2006
  • The rising cost of glaucoma drugs in Ireland. 1996-2003.
  • Br J Ophthalmol 2006 Feb;90(2):162-5
Reference Link
084

McKernan DP, Caplis C, Donovan M, O’Brien C, Cotter T.

  • 2006
  • Age-dependent susceptibility of the retinal ganglion cell layer to cell death.
  • Invest Ophthalmol Vis Sci. 2006 Mar;47(3):807-14.
Reference Link
085

C Kelliher, D Kenny, C O’Brien.

  • 2006
  • Trends in blind registration in the adult population of the Republic of Ireland. 1996-2003.
  • Br J Ophthalmol 2006 Mar;90(3)367-71.
Reference Link
086

L Cryan, G Pidgeon, D Fitzgerald, C O’Brien.

  • 2006
  • COX-2 protects against thrombosis of the retinal vasculature in a mouse model of proliferative retinopathy.
  • Mol Vis. 2006 Apr 20;12:405-14
Reference Link
087

E Henry, D Newby, DJ Webb, PW Hadoke, C O’Brien.

  • 2006
  • Altered endothelin-1 vasoreactivity in patients with untreated normal-pressure glaucoma.
  • Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2528-32.
Reference Link
088

Y Delaney, T Walshe, C O’Brien.

  • 2006
  • Vasospasm in glaucoma: clinical and laboratory aspects.
  • Optom Vis Sci. 2006 Jul;83(7):406-14.
Reference Link
089

Guerin MB, McKernan DP, O’Brien CJ, Cotter TG.

  • 2006
  • Retinal ganglion cells: dying to survive.
  • Int J Dev Biol. 2006;50(8):665-74..
Reference Link
090

McKernan DP, Guerin MB, O’Brien CJ, Cotter TG. A key role for calpains in retinal ganglion cell death.

  • 2007
  • Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5420-30.
Reference Link
091

Lee H, O’Meara SJ, O’Brien C, Kane R.

  • 2007
  • The role of gremlin, a BMP antagonist, and epithelial-to-mesenchymal transition in proliferative vitreoretinopathy.
  • Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4291-9.
Reference Link
092

Connell P, Walshe T, Ferguson G, Gao W, O’Brien C, Cahill PA.

  • 2007
  • Elevated glucose attenuates agonist- and flow-stimulated endothelial nitric oxide synthase activity in microvascular retinal endothelial cells.
  • Endothelium. 2007 Jan-Feb;14(1):17-24.
Reference Link
093

Gao W, Ferguson G, Connell P, Walshe T, Murphy R, Birney YA, O’Brien C, Cahill PA.

  • 2007
  • High glucose concentrations alter hypoxia-induced control of vascular smooth muscle cell growth via a HIF-1alpha-dependent pathway.
  • J Mol Cell Cardiol. 2007 Mar;42(3):609-19. Epub 2006 Dec 21.
Reference Link
094

Horgan N, Kirwan RP, O’Brien CJ.

  • 2007
  • Choroidal detachment associated with latanoprost use in the fellow eye.
  • Ann Pharmacother. 2007 Jan;41(1):161-2.
Reference Link
095

Cryan LM, Paraoan L, Hiscott P, Damato BE, Grierson I, Gray D, Farrell M, Doherty GA, Fitzgerald DJ, O’Brien C.

  • 2008
  • Expression of COX-2 and prognostic outcome in uveal melanoma.
  • Curr Eye Res. 2008 Feb;33(2):177-84.
Reference Link
096

Aragon-Martin JA, Ritch R, Liebmann J, O’Brien C, Blaaow K, Mercieca F, Spiteri A, Cobb CJ, Damji KF, Tarkkanen A, Rezaie T, Child AH, Sarfarazi M.

  • 2008
  • Evaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma.
  • Mol Vis. 2008 Mar 17;14:533-41.
Reference Link
097

O’Driscoll C, O’Connor J, O’Brien CJ, Cotter TG.

  • 2008
  • Basic fibroblast growth factor-induced protection from light damage in the mouse retina in vivo.
  • J Neurochem. 2008 Apr;105(2):524-36. Epub 2007 Dec 13.
Reference Link
098

Kane R, Godson C, O’Brien C.

  • 2008
  • Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis.
  • Mol Vis. 2008 Jun 20;14:1138-48.
Reference Link
099

O’Connor JC, Wallace DM, O’Brien C, Cotter TG. A novel antioxidant function for the tumour suppressor gene p53 in the retinal ganglion cell.

  • 2008
  • A novel antioxidant function for the tumour suppressor gene p53 in the retinal ganglion cell.
  • Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4237-44
Reference Link
100

Morrow D, Guha S, Sweeney C, Birney Y, Walshe T, O’Brien C, Walls D, Redmond EM, Cahill PA.

  • 2008
  • Notch and vascular smooth muscle cell phenotype.
  • Circ Res. 2008 Dec 5;103(12):1370-82.
Reference Link
101

Cryan L, O’Brien C.

  • 2008
  • Proteomics as a research tool in clinical and experimental ophthalmology.
  • Proteomics Clin. App. 2008; 2(5); 762-75
Reference Link
102

Guerin M, Flynn T, Brady J, O’Brien C.

  • 2008
  • Worldwide geographical distribution of ophthalmic publications.
  • Int Ophthalmol; 2008; 29: 511-6.
Reference Link
103

Cryan L, Fitzgerald D, O’Brien C.

  • 2009
  • Ocular prostaglandin production and morphology in mice lacking a single isoform of cyclogenase.
  • Prostaglandins, Leuko & Essent Fatty Acids 2009 81:401-9.
Reference Link
104

Irnaten M, Barry RC, Quill B, Clark AF, Harvey BJ, O’Brien CJ.

  • 2009
  • Activation of stretch-activated channels and maxi-K+ channels by membrane stress of human lamina cribrosa cells.
  • Invest Ophthalmol Vis Sci. 2009 Jan;50(1):194-202. Epub 2008 Sep 4.
Reference Link
105

Kirwan RP, Wordinger RJ, Clark AF, O’Brien CJ.

  • 2009
  • Differential global and extra-cellular matrix focused gene expression patterns between normal and glaucomatous human lamina cribrosa cells.
  • Mol Vis. 2009;15:76-88. Epub 2009 Jan 15.
Reference Link
106

Quaranta L, Konstas AG, Rossetti L, Garcia-Feijoo J, O’Brien C, Nasr MB, Fogagnolo P, Demos CM, Stewart JA, Stewart WC.

  • 2010
  • Untreated 24-h intraocular pressures measured with Goldmann applanation tonometry vs nighttime supine pressures with Perkins applanation tonometry.
  • Eye (Lond). 2010 Jul;24(7):1252-8. Epub 2009 Dec 4.
Reference Link
107

Dervan EW, Chen H, Ho SL, Brummel N, Schmid J, Toomey D, Haralambova M, Gould E, Wallace DM, Prehn JH, O’Brien C, Murphy D.

  • 2010
  • Protein Macroarray Profiling of Serum Autoantibodies in Pseudoexfoliation Glaucoma.
  • Invest Ophthalmol Vis Sci. 2010 Jun;51(6):2968-75.
Reference Link
108

P O’Connor R, Cryan LM, Wynne K, de Stefani A, Fitzgerald D, O’Brien C, Cagney G.

  • 2010
  • Proteomics strategy for identifying candidate bioactive proteins in complex mixtures: application to the platelet releasate.
  • J Biomed Biotechnol. 2010; 2010:107859.
Reference Link
109

Walshe TE, Connell P, Cryan L, Ferguson G, O’Brien C, Cahill PA.

  • 2011
  • The role of pulsatile flow in controlling microvascular retinal endothelial and pericyte cell apoptosis and proliferation.
  • Cardiovasc Res. 2011 Feb 15;89(3):661-70.
Reference Link
110

Farrell SM, Groeger G, Bhatt L, Finnegan S, O’Brien CJ, Cotter TG.

  • 2011
  • bFGF-mediated redox activation of the PI3K/Akt pathway in retinal photoreceptor cells.
  • Eur J Neurosci. 2011 Feb;33(4):632-41.
Reference Link
111

Quill B, Docherty N, Clark AF, O’Brien CJ.

  • 2011
  • The Effect of Graded Cyclic Stretch on Extracellular Matrix Related Gene Expression Profiles in Cultured Primary Human Lamina Cribrosa Cells.
  • Invest Ophthalmol Vis Sci. 2011; Mar 30;52(3):1908-15.
Reference Link
112

Guerin M, Cotter T, McKernan D, O’Brien C.

  • 2011
  • Age Dependent Rat Retinal Ganglion Cell Susceptibility to Apoptotic Stimuli: Implications for Glaucoma.
  • Clin & Exper Ophthalmol Apr;39(3):243-51. 2011
Reference Link
113

McElnea EM, Quill B, Docherty NG, Irnaten M, Siah WF, Clark AF, O’Brien CJ, Wallace DM

  • 2011
  • Oxidative stress, mitochondrial dysfunction and calcium overload in human lamina cribrosa cells from glaucoma donors.
  • Mol Vis. 2011;17:1182-91.
Reference Link
114

Gallagher BA, Hart PM, O’Brien C, Stevenson MR, Jackson AJ.

  • 2011
  • Mobility and access to transport issues as experienced by people with vision impairment living in urban and rural Ireland.
  • Disabil Rehabil. 2011;33(12):979-88.
Reference Link
115

Browne JG, Ho SL, Kane R, Oliver N, Clark AF, O’Brien CJ, Crean JK.

  • 2011
  • Connective Tissue Growth Factor is increased in Pseudoexfoliation Glaucoma.
  • Invest Ophthalmol Vis Sci. 2011 Jun 1;52(6):3660-6
Reference Link
116

Walshe TE, Connell P, Cryan L, Ferguson G, Gardiner T, Morrow D, Redmond EM, O’Brien C, Cahill PA

  • 2011
  • Microvascular retinal endothelial and pericyte cell apoptosis in vitro: role of Hedgehog and Notch signaling.
  • Invest Ophthalmol Vis Sci. 2011 . Jun 23;52(7):4472-83.
Reference Link
117

Wiggs JL, Hewitt AW, Fan BJ, Wang DY, Figueiredo Sena DR, O’Brien C, Realini A, Craig JE, Dimasi DP, Mackey DA, Haines JL, Pasquale LR.

  • 2012
  • The p53 codon 72 PRO/PRO genotype may be associated with initial central visual field defects in caucasians with primary open angle glaucoma.
  • PLoS One. 2012;7(9):e45613. doi: 10.1371/journal.pone.0045613. Epub 2012 Sep 26
Reference Link
118

Kirwan RP, Felice L, Clark AF, O’Brien CJ, Leonard MO.

  • 2012
  • Hypoxia regulated gene transcription in human optic nerve lamina cribrosa cells in culture.
  • Invest Ophthalmol Vis Sci. 2012 53:2243-2255
Reference Link
119

Bhattacharya SK, Lee RK, Grus FH; 

  • 2013
  • Seventh ARVO/Pfizer Ophthalmics Research Institute Conference Working Group. Molecular biomarkers in glaucoma.
  • 2013 Jan 7;54(1):121-31
120

Igras E, Loughman J, Ratzlaff M, O’Caoimh R, O’Brien C.

  • 2013
  • Evidence of lower macular pigment optical density in chronic open angle glaucoma. Br J Ophthalmol. 2013 Aug;97(8):994-998
  • Br J Ophthalmol. 2013 Aug;97(8):994-998
Reference Link
121

Irnaten M, Barry RC, Wallace DM, Docherty NG, Quill B, Clark AF, O’Brien CJ.

  • 2013
  • Elevated maxi-K(+) ion channel current in glaucomatous lamina cribrosa cells
  • Exp Eye Res 2013 Oct; 115:224-9
Reference Link
122

Wallace DM, Clarke AF, Lipson KE, Andrews D, Crean JK, O’Brien CJ .

  • 2013
  • Anti-connective tissue growth factor antibody treatment reduces extracellular matrix production in trabecular meshwork and lamina cribrosa cells.
  • Invest Ophthalmol Vis Sci 2013 Dec 2;54(13)7836-48
Reference Link
123

Wallace DM, Murphy-Ullrich JE, Downs JC, O’Brien CJ

  • 2014
  • The role of matricellular proteins in glaucoma.
  • Matrix Biol 2014 Apr 12 pii S0945-053X(14)00058-4
Reference Link
124

McDonnell F, O’Brien C, Wallace D.

  • 2014
  • The role of epigenetics in the fibrotic processes associated with glaucoma.
  • J Ophthalmol. 2014~:750459.
Reference Link
125

Gao W, Ferguson G, Connell P, Walshe T, O’Brien C, Redmond EM, Cahill PA.

  • 2014
  • Glucose attenuates hypoxia-induced changes in endothelial cell growth by inhibiting HIF-1α expression.
  • Diab Vasc Dis Res. 2014 May 22;11(4):270-280.
Reference Link
126

Sundaresan P, Simpson DA, Sambare C, Duffy S, Lechner J, Dastane A, Dervan EW, Vallabh N, Chelerkar V, Deshpande M, O’Brien C, McKnight AJ, Willoughby CE

  • 2014
  • Whole-mitochondrial genome sequencing in primary open-angle glaucoma using massively parallel sequencing identifies novel and known pathogenic variants.
  • Genet Med. 2014 Sep 18.
Reference Link
127

McNally S,  O’Brien CJ. Metabolomics/Proteomics strategies used to identify biomarkers for exfoliation glaucoma. J Glaucoma. 2014 Oct-Nov;23(8 Suppl 1):S51-4.

  • 2014
  • Metabolomics/Proteomics strategies used to identify biomarkers for exfoliation glaucoma.
  • J Glaucoma. 2014 Oct-Nov;23(8 Suppl 1):S51-4.
Reference Link
128

McElnea EM, Hughes E, McGoldrick A, McCann A, Quill B, Docherty N, Irnaten M, Farrell M, Clark AF, O’Brien CJ, Wallace DM.

  • 2014
  • Lipofuscin accumulation and autophagy in glaucomatous human lamina cribrosa cells.
  • BMC Ophthalmol. 2014 Dec 2;14:153.
Reference Link
129

Quill B, Irnaten M, Docherty NG, McElnea EM, Wallace DM, Clark AF, O’Brien CJ

  • 2015
  • ‘Calcium channel blockade reduces mechanical strain induced extracellular matrix gene response in lamina cribrosa cells’.
  • Br J Ophthalmol. 2015 Mar 20. pii: bjophthalmol-2014-306093. doi: 10.1136/bjophthalmol-2014-306093. [Epub ahead of print]
Reference Link
130

Wallace DM, Pokrovskaya O, O’Brien CJ.

  • 2015
  • The function of matricellular proteins in the lamina cribrosa and trabecular meshwork in glaucoma.
  • J Ocul Pharmacol Ther. 2015 Apr 7. [Epub ahead of print]
Reference Link
131

Murphy RM, Bakir B, O’Brien C, Wiggs JL, Pasquale LR

  • 2015
  • Drug-induced Bilateral Secondary Angle-Closure Glaucoma: A Literature Synthesis.
  • J Glaucoma. 2015 Apr 21. [Epub ahead of print]
Reference Link
132

Wallace DM, Pokrovskaya O, O’Brien CJ.

  • 2015
  • The Function of Matricellular Proteins in the Lamina Cribrosa and Trabecular Meshwork in Glaucoma.
  • J Ocul Pharmacol Ther. 2015 Sep;31(7):386-95.
Reference Link
133

Siah WF, Loughman J, O’Brien C.

  • 2015
  • Lower Macular Pigment Optical Density in Foveal-Involved Glaucoma.
  • Ophthalmology. 2015 Oct;122(10):2029-37.
Reference Link
134

Quill B, Henry E, Simon E, O’Brien CJ.

  • 2015
  • Evaluation of the Effect of Hypercapnia on Vascular Function in Normal Tension Glaucoma.
  • Biomed Res Int. 2015;2015:418159.
Reference Link
135

Wallace DM, O’Brien CJ. The role of lamina cribrosa cells in optic nerve head fibrosis in glaucoma.

  • 2016
  • The role of lamina cribrosa cells in optic nerve head fibrosis in glaucoma.
  • Exp Eye Res. 2016 Jan;142:102-9.
Reference Link
136

O’Brien C, Clark AF.

  • 2016
  • Introduction to EER Special Issue on ocular fibrosis.
  • Exp Eye Res. 2016 Jan;142:1.
Reference Link
137

Murphy RM, Bakir B, O’Brien C, Wiggs JL, Pasquale LR.

  • 2016
  • Drug-induced Bilateral Secondary Angle-Closure Glaucoma: A Literature Synthesis.
  • J Glaucoma. 2016 Feb;25(2):e99-e105.
Reference Link
138

Pokrovskaya O, O’Brien C.

  • 2016
  • What's in a Gene? Pseudoexfoliation Syndrome and Pigment Dispersion Syndrome in the Same Patient.
  • Case Rep Ophthalmol. 2016 Jan 21;7(1):54-60. doi: 10.1159/000443697. eCollection 2016 Jan 21.
Reference Link
139

McDonnell F, Irnaten M, Clark AF, O’Brien CJ, Wallace DM.

  • 2016
  • Hypoxia-Induced Changes in DNA Methylation Alter RASAL1 and TGFβ1 Expression in Human Trabecular Meshwork Cells.
  • PLoS One. 2016 Apr 28;11(4):e0153354. doi: 10.1371/journal.pone.0153354. eCollection 2016 Apr 28.
Reference Link
140

Treacy MP, O’Neill EC, Murphy M, O’Toole L, Delaney Y, O’Brien C, Connell PP.

  • 2016
  • Opportunistic detection of glaucomatous optic discs within a diabetic retinopathy screening service.
  • Eur J Ophthalmol. 2016 Jun 10;26(4):315-20. doi: 10.5301/ejo.5000722. Epub 2015 Dec 17.
Reference Link
141

Paula JS, O’Brien C, Stamer WD.

  • 2016
  • Life under pressure: The role of ocular cribriform cells in preventing glaucoma.
  • Exp Eye Res. 2016 Oct;151:150-9. doi: 10.1016/j.exer.2016.08.014. Epub 2016 Aug 25. Review.
Reference Link
142

McDonnell FS, McNally SA, Clark AF, O’Brien CJ, Wallace DM.

  • 2016
  • Increased Global DNA Methylation and Decreased TGFβ1 Promoter Methylation in Glaucomatous Lamina Cribrosa Cells.
  • J Glaucoma. 2016 Oct;25(10):e834-e842.
Reference Link
143

Murphy ML, Pokrovskaya O, Galligan M, O’Brien C.

  • 2017
  • Corneal hysteresis in patients with glaucoma-like optic discs, ocular hypertension and glaucoma.
  • BMC Ophthalmol. 2017 Jan 10;17(1):1. doi: 10.1186/s12886-016-0396-9.
Reference Link
144

O’Callaghan J, Crosbie DE, Cassidy PS, Sherwood JM, Flügel-Koch C, Lütjen-Drecoll E, Humphries MM, Reina-Torres E, Wallace D, Kiang AS, Campbell M, Daniel SW, Overby DR, O’Brien C, Tam LC, Humphries P.

  • 2017
  • Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma.
  • Hum Mol Genet. 2017 Feb 1. doi: 10.1093/hmg/ddx028.
Reference Link
145

Wallace DM, Pokrovskaya O, O’Brien CJ.

  • 2015
  • The Function of Matricellular Proteins in the Lamina Cribrosa and Trabecular Meshwork in Glaucoma.
  • J Ocul Pharmacol Ther. 2015 Sep;31(7):386-95. doi: 10.1089/jop.2014.0163. Epub 2015 Apr 7. Review.
Reference Link
146

Barrett C, O’Brien C, Butler JS, Loughman J.

  • 2017
  • Barriers to glaucoma case finding as perceived by optometrists in Ireland.
  • Clin Exp Optom. 2017 Jul 17. doi: 10.1111/cxo.12573.
Reference Link
147

Liu B, McNally S, Kilpatrick JI, Jarvis SP, O’Brien CJ.

  • 2017
  • Aging and ocular tissue stiffness in glaucoma.
  • Surv Ophthalmol. 2017 Jun 27. pii: S0039-6257(15)30018-7. doi: 10.1016/j.survophthal.2017.06.007
Reference Link
148

Kamel K, Farrell M, O’Brien C.

  • 2017
  • Mitochondrial dysfunction in ocular disease: Focus on glaucoma.
  • Mitochondrion. 2017 Jul;35:44-53. doi: 10.1016/j.mito.2017.05.004. Epub 2017 May 9.
Reference Link
149

Siah WF, O’Brien C, Loughman JJ.

  • 2017
  • Macular pigment is associated with glare-affected visual function and central visual field loss in glaucoma.
  • Br J Ophthalmol. 2017 Oct 5. pii: bjophthalmol-2017-310215. doi: 10.1136/bjophthalmol-2017-310215. [Epub ahead of print]
Reference Link
150

Liu B, Kilpatrick JI, Lukasz B, Jarvis SP, McDonnell F, Wallace DM, Clark AF, O’Brien CJ.

  • 2018
  • Increased Substrate Stiffness Elicits a Myofibroblastic Phenotype in Human Lamina Cribrosa Cells.
  • Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):803-814. doi: 1
Reference Link
151

Irnaten M, Zhdanov A, Brennan D, Crotty T, Clark A, Papkovsky D, O’Brien C.

  • 2018
  • Activation of the NFAT-Calcium Signaling Pathway in Human Lamina Cribrosa Cells in Glaucoma.
  • Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):831-842. doi: 10.1167/iovs.17-22531.
Reference Link
152

Barrett C, O’Brien C, Loughman J.

  • 2018
  • Glaucoma referral refinement in Ireland: managing the sensitivity-specificity paradox in optometric practice.
  • Ophthalmic Physiol Opt. 2018 Feb 28. doi: 10.1111/opo.12446
Reference Link
153

Kamel K, Falzan K, Dervan E, O’Brien C.

  • 2018
  • Difference in intraocular pressure measurements between non-contact tonometry and Goldman applanation tonometry
  • Ir J Med Sci. 2018
Reference Link
154

Kamel K, Bourke L, O’Brien C.

  • 2018
  • Clinical and Laboratory Biomarkers for Pseudoexfoliation Syndrome.
  • J Glaucoma. 2018 Jul;27 Suppl 1:S111-S113.
Reference Link
155

Loskutova E, O’Brien C, Loskutov I, Loughman J.

  • 2018
  • Nutritional supplementation in the treatment of glaucoma: A systematic review.
  • Surv Ophthalmol. 2018 Oct 6. pii: S0039-6257(18)30100-0.
Reference Link
156

Andrews D, Oliviero G, De Chiara L, Watson A, Rochford E, Wynne K, Kennedy C, Clerkin S, Doyle B, Godson C, Connell P, O’Brien C, Cagney G, Crean J.

  • 2019
  • Unravelling the transcriptional responses of TGF-β: Smad3 and EZH2 constitute a regulatory switch that controls neuroretinal epithelial cell fate specification.
  • FASEB J. 2019 May;33(5):6667-6681. doi: 10.1096/fj.201800566RR
Reference Link
157

Bourke CM, Loughman J, Fltcroft DI, Loskutova E, O’Brien C.

  • 2019
  • We can't afford to turn a blind eye to myopia.
  • QJM. 2019 Mar 26. pii: hcz076. doi: 10.1093/qjmed/hcz076.
Reference Link
158

Murtagh P, Greene G, O’Brien C.

  • 2020
  • Current application of machine learning in the screening and diagnosis of glaucoma: a systematic review and Meta-analysis.
  • Int J Ophthalmic. 2020 Jan18;13(1):149-162
Reference Link
159

Greene AG, Eivers SB, Dervan EWJ,O’Brien CJ, Wallace DM.

  • 2020
  • Lysyl Oxidase Like 1: Biological roles and regulation.
  • Exp Eye Res. 2020 Apr;193107975. doi:10.1016/j.exer.2020.107975. Epub 2020 Feb15.
Reference Link
160

Iraten M, O’Malley G, Clark AF, O’Brien CJ.

  • 2020
  • Transient receptor potential channels TRPC1/TRPC6 regulate lamina cribrosa cell extracellular matrix gene transcription and proliferation.
  • Exp Eye Res. 2020 Apr;193:107980. doi: 10.1016/j.exer.2020.107980. Epub 2020 Feb 20.
Reference Link
161

Eivers SB, Greene AG, Dervan E, O’Brien C, Wallace D

  • 2020
  • Prevalence of Pseudoexfoliation Glaucoma Risk-associated Variants Within Lysyl Oxidase-like 1 in an Irish Population.
  • J Glaucoma. 2020 Jun;29(6):417-422. doi:10.1097/IJG.0000000000001475.
Reference Link
162

Rahman N, O’Neill E, Irnaten M, Wallace D, O’Brien C.

  • 2020
  • Corneal Stiffness and Collagen Cross-Linking Proteins in Glaucoma: Potential for Novel Therapeutic Strategy.
  • J Ocul Pharmacol Ther. 2020 Jul 13. doi: 10.1089/jop.2019.0118.
Reference Link
163

Hopkins AA, Murphy R, Irnaten M, Wallace DM, Quill B, O’Brien C.

  • 2020
  • The Role of Lamina Cribrosa Tissue Stiffness and Fibrosis as Fundamental Biomechanical Drivers of Pathological Glaucomatous Cupping.
  • Am J Physiol Cell Physiol. 2020 Jul 15. doi: 10.1152/ajpcell.00054.2020.
Reference Link
164

Kamel K, O’Brien CJ, Zhdanov AV, Papkovsky DB, Clark AF, Stamer WD, Irnaten M.

  • 2020
  • Reduced Oxidative Phosphorylation and Increased Glycolysis in Human Glaucoma Lamina Cribrosa Cells.
  • Invest Ophthalmol Vis Sci. 2020 Nov 2;61(13):4. doi: 10.1167/iovs.61.13.4.
Reference Link
165

Irnaten M, Duff A, Clark A, O’Brien C.

  • 2020
  • Intra-Cellular Calcium Signaling Pathways (PKC, RAS/RAF/MAPK, PI3K) in Lamina Cribrosa Cells in Glaucoma.
  • J Clin Med. 2020 Dec 26;10(1):62. doi: 10.3390/jcm10010062.
Reference Link
166

Greene AG, Eivers SB, McDonnell F, Dervan EWJ, O’Brien CJ, Wallace DM.

  • 2020
  • Differential Lysyl oxidase like 1 expression in pseudoexfoliation glaucoma is orchestrated via DNA methylation.
  • Exp Eye Res. 2020 Dec;201:108349. doi: 10.1016/j.exer.2020.108349. Epub 2020
Reference Link
167

Cassidy PS, Kelly RA, Reina-Torres E, Sherwood JM, Humphries MM, Kiang AS, Farrar GJ, O’Brien C, Campbell M, Stamer WD, Overby DR, Humphries P, O’Callaghan J.

  • 2020
  • siRNA targeting Schlemm's canal endothelial tight junctions enhances outflow facility and reduces IOP in a steroid-induced OHT rodent model.
  • Mol Ther Methods Clin Dev. 2020 Oct 31;20:86-94. doi: 10.1016/j.omtm.2020.10.022. eCollection 2021 Mar 12.
Reference Link
168

Kamel K, Dervan E, Falzon K, O’Brien C.

  • 2020
  • Difference in intraocular pressure measurements between non-contact tonometry and Goldmann applanation tonometry and the role of central corneal thickness in affecting glaucoma referrals.
  • Ir J Med Sci. 2019 Feb;188(1):321-325. doi: 10.1007/s11845-018-1795-0. Epub 2018 Apr 4.
Reference Link
169

Doolan E, O’Brien C.

  • 2021
  • Abnormal corneal properties in osteogenesis imperfect and glaucoma: a case series.
  • BMJ Open Ophthalmic. 2021 Apr15;6(1):e000684 doi: 10.1136/bmjophth-2020-000684. eCollection 2021.
Reference Link
170

O’Regan A, O’Brien CJ, Eivers SB.

  • 2021
  • The lysophosphatidic acid axis in fibrosis: Implications for glaucoma.
  • Wound Repair Regen. 2021 Jul;29(4):613-626. doi: 10.1111/wrr.12929. Epub 2021 May 19.
Reference Link
171

Hurley DJ, Iranaten, O’Brien C.

  • 2021
  • Metformin and Glaucoma-Review of Anti-Fibrotic Processes and Bioenergetics.
  • Cells 2021 Aug 19;10(8):2131. Doi: 10.3390/cells10082131.
Reference Link
172

Kelly RA, Perkumas KM, Campbell M, Farrar GJ, Stamer WD, Humphries P, O’Callaghan J, O’Brien CJ.

  • 2021
  • Fibrotic Changes to Schlemm’s Canal Endothelial Cells in Glaucoma.
  • Int J Mol Sci. 2021 Aug 31;22(17):9446. Doi 10.3390/ijms22179446.
Reference Link
173

Murphy R, Irnaten M, Hopkins A, O Callaghan J, Stamer WD, Clark AF, Wallace D, O’Brien CJ.

  • 2022
  • Matrix Mechanotransduction via Yes-Associated Protein in Human Lamina Cribosa Cells in Glaucoma.
  • Invest Ophthalmol Vis Sci. 2022 Jan 3;63(1):16 doi: 10.1167/iovs.63.1.16.
Reference Link
174

Powell S, Doolan E, Curtin K, Doyle A, O’Brien C.

  • 2022
  • Audit of outcomes following attendance at the City West drive-through IOP glaucoma clinic during COVID-19 pandemic.
  • Ir J Med Sci. 2022 Jan 16:1-10. doi: 10.1007/s11845-021-02893-9.
Reference Link
175

Powell S, Irnaten M, O’Brien C.

  • 2022
  • Glaucoma – A Stiff Eye in a Stiff Body
  • Curr Eye Res. 2022 Mar 7:1-9. doi: 10.1080/02713683.2022.2039204.
reference Link
176

Hurley DJ, Normile C, Irnaten M, O’Brien C.

  • 2022
  • The Intertwined Roles of Oxidative Stress and Endoplasmic Reticulum Stress in Glaucoma.
  • Antioxidants (Basel). 2022 Apr 29;11(5):886. doi: 10.3390/antiox11050886
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